10/26 Analysis of outcomes based on serum levels
et al., Metabolites, doi:10.3390/metabo11090565 (preprint 10/26/2020) (Peer Reviewed)
Low Levels of Few Micronutrients May Impact COVID-19 Disease Progression: An Observational Study on the First Wave
Low Levels of Few Micronutrients May Impact COVID-19 Disease Progression: An Observational Study on the First Wave
Retrospective 120 hospitalized patients in Spain showing no significant differences for vitamin D deficiency.
Tomasa-Irriguible et al., 10/26/2020, retrospective, Spain, Europe, peer-reviewed, 7 authors.
risk of mechanical ventilation, 35.0% lower, RR 0.65, p = 0.21, high D levels 15 of 27 (55.6%), low D levels 18 of 78 (23.1%), adjusted per study, odds ratio converted to relative risk, ≥20 ng/mL, bivariate logistic regression.
risk of ICU admission, 16.9% lower, RR 0.83, p = 0.58, high D levels 0 of 27 (0.0%), low D levels 17 of 78 (21.8%), adjusted per study, odds ratio converted to relative risk, ≥20 ng/mL, bivariate logistic regression.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.
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