Hernández, 216 patient vitamin D sufficiency study: 83% lower combined mortality/ICU admission [p=0.0001], 81% lower hospitalization [p=0.0001], 76% lower ventilation [p=0.13], and 79% lower ICU admission [p=0.05] https://c19p.org/hernandez
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Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection
et al., The Journal of Clinical Endocrinology & Metabolism, doi:10.1210/clinem/dgaa733
Retrospective 216 COVID-19 patients and 197 population controls, showing vitamin D deficiency in 82.2% of COVID-19 cases and 47.2% of population-based controls (P < .0001). Authors note: "We did not find any relationship between vitamin D concentrations or vitamin deficiency and the severity of the disease". While no association was found within hospitalized patients, there is an association with hospitalization, and hospitalization is an indication of COVID-19 severity.19 of the COVID-19 patients were taking vitamin D supplements, showing lower ventilation and ICU admission, but no significant difference in mortality.
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risk of combined death/ICU/ventilation, 83.0% lower, RR 0.17, p < 0.001, high D levels 35, low D levels 162, >= 20ng/mL risk of hospitalization * risk of death/ICU/ventilation | hospitalization.
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risk of combined death/ICU/ventilation if hospitalized, 12.0% lower, RR 0.88, p = 0.86, high D levels 35, low D levels 162, >= 20ng/mL risk of death/ICU/ventilation | hospitalization.
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risk of hospitalization, 80.6% lower, RR 0.19, p < 0.001, >= 20ng/mL.
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risk of death, 3.7% higher, RR 1.04, p = 1.00, high D levels 2 of 19 (10.5%), low D levels 20 of 197 (10.2%), supplementation.
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risk of mechanical ventilation, 75.9% lower, RR 0.24, p = 0.13, high D levels 1 of 19 (5.3%), low D levels 43 of 197 (21.8%), NNT 6.0, supplementation.
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risk of ICU admission, 79.3% lower, RR 0.21, p = 0.05, high D levels 1 of 19 (5.3%), low D levels 50 of 197 (25.4%), NNT 5.0, supplementation.
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hospitalization time, 33.3% lower, relative time 0.67, p = 0.11, high D levels 19, low D levels 197, supplementation.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Hernández et al., 10/27/2020, retrospective, Spain, Europe, peer-reviewed, mean age 60.9, 12 authors.
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