Interaction between age and vitamin D deficiency in severe COVID-19 infection

Vitamin D study #35 of 131 Meta Analysis

10/21 Analysis of outcomes based on serum levels

Macaya et al., Nutr. Hosp., doi:10.20960/nh.03193 (Peer Reviewed)
Interaction between age and vitamin D deficiency in severe COVID-19 infection

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Retrospective 80 hospitalized patients in Spain showing higher risk of severe COVID-19 with vitamin D deficiency.

Macaya et al., 10/21/2020, retrospective, Spain, Europe, peer-reviewed, 8 authors.

risk of COVID-19 severe case, 55.0% lower, RR 0.45, p = 0.07, high D levels 11 of 35 (31.4%), low D levels 20 of 45 (44.4%), odds ratio converted to relative risk, >20ng/mL.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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