Influence of anti-osteoporosis treatments on the incidence of COVID-19 in patients with non-inflammatory rheumatic conditions

Vitamin D study #34 of 131 Meta Analysis

10/20 Pre-Exposure Prophylaxis study (treated before exposed to the virus)

Blanch-Rubió et al., Aging, doi:10.18632/aging.104117 (Peer Reviewed)
Influence of anti-osteoporosis treatments on the incidence of COVID-19 in patients with non-inflammatory rheumatic conditions

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Retrospective 2,102 rheumatology patients in Spain showing lower, but not statistically significant, cases with vitamin D supplementation. Details of vitamin D supplementation are not providied - other patients may have also independently taken vitamin D.

Blanch-Rubió et al., 10/20/2020, retrospective, Spain, Europe, peer-reviewed, 10 authors, dosage not specified.

risk of COVID-19 case, 8.0% lower, RR 0.92, p = 0.68, treatment 62 of 1303 (4.8%), control 47 of 799 (5.9%), adjusted per study.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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