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0 0.5 1 1.5 2+ Hospitalization, G1 vs. G2 -74% Improvement Relative Risk Case, G1 vs. G2 79% Case, G1 vs. G2 (b) 59% Case, G1 vs. G2 (c) 79% ICU admission, G3 vs. G4 57% Hospitalization, G3 vs. G4 -350% Case, G3 vs. G4 -15% Case, G3 vs. G4 (b) 32% Case, G3 vs. G4 (c) 22% Romero-Ibarguengoitia et al. NCT04810949 Vitamin D RCT Prophylaxis Favors vitamin D Favors diet/sun
Romero-Ibarguengoitia, 112 patient vitamin D prophylaxis RCT: 79% fewer cases [p=0.008]
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Effect of Vitamin D3 supplementation vs. dietary-hygienic measures on SARS-COV-2 infection rates in hospital workers with 25-hydroxyvitamin D3 [25(OH)D3] levels >20 ng/mL
Romero-Ibarguengoitia et al., medRxiv, doi:10.1101/2022.07.12.22277450 (Preprint), NCT04810949 (history)
15 Jul 2022    Source   PDF   Share   Tweet
RCT healthcare workers with vitamin D levels between 20-100 ng/mL, 43 treated with vitamin D 52,000 IU monthly, and 42 with dietary-hygienic measures, which were also focused on increasing vitamin D, including sun exposure for at least 10 minutes per day between 10:00-18:00, and consuming foods rich in vitamin D. There was significantly lower risk of COVID-19 with supplementation vs. diet/sun. Authors also report on patients with levels <20 ng/mL where treatment was recommended for all patients, however many patients declined treatment. In these non-randomized patients, lower risk was seen at 4 months with vitamin D supplementation, however there was no significant difference at 6 months.
Interpretation of the results is difficult because all groups had intervention aimed at increasing vitamin D. Supplemented patients showed greater improvement in levels, however dietary/sun patients could have a therapeutic advantage due to regular versus monthly consumption, and due to other benefits of the dietary/sun intervention. Authors indicate they asked patients monthly about consumption of food with vitamin D, however no results are provided.
risk of hospitalization, 73.7% higher, RR 1.74, p = 1.00, treatment 2 of 38 (5.3%), control 1 of 33 (3.0%), G1 vs. G2.
risk of case, 79.0% lower, HR 0.21, p = 0.008, treatment 5 of 38 (13.2%), control 13 of 33 (39.4%), NNT 3.8, 6 months, Cox proportional hazards, G1 vs. G2.
risk of case, 59.1% lower, RR 0.41, p = 0.04, treatment 6 of 43 (14.0%), control 14 of 41 (34.1%), NNT 5.0, 4 months, G1 vs. G2.
risk of case, 79.1% lower, RR 0.21, p = 0.003, treatment 3 of 43 (7.0%), control 14 of 42 (33.3%), NNT 3.8, 3 months, G1 vs. G2.
risk of ICU admission, 57.1% lower, RR 0.43, p = 1.00, treatment 0 of 24 (0.0%), control 1 of 72 (1.4%), NNT 72, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), G3 vs. G4.
risk of hospitalization, 350.0% higher, RR 4.50, p = 0.10, treatment 3 of 24 (12.5%), control 2 of 72 (2.8%), G3 vs. G4.
risk of case, 15.0% higher, HR 1.15, p = 0.72, treatment 9 of 24 (37.5%), control 29 of 72 (40.3%), 6 months, Cox proportional hazards, G3 vs. G4.
risk of case, 32.1% lower, RR 0.68, p = 0.35, treatment 7 of 27 (25.9%), control 29 of 76 (38.2%), NNT 8.2, 4 months, G3 vs. G4.
risk of case, 22.2% lower, RR 0.78, p = 0.64, treatment 7 of 28 (25.0%), control 27 of 84 (32.1%), NNT 14, 3 months, G3 vs. G4.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Romero-Ibarguengoitia et al., 15 Jul 2022, Randomized Controlled Trial, Mexico, preprint, mean age 44.4, 5 authors, study period May 2020 - August 2020, dosage 52,000IU single dose, monthly, this trial compares with another treatment - results may be better when compared to placebo, trial NCT04810949 (history).
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