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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality -70% Improvement Relative Risk Mechanical ventilation -10% ICU admission -30% Mortality (b) 36% Mechanical ventilation (b) 57% ICU admission (b) -13% c19vitamind.com/pecina.html Favors vitamin D Favors control
27 August 2021 - Prophylaxis study
Vitamin D Status and Severe COVID-19 Disease Outcomes in Hospitalized Patients
Pecina et al., Journal of Primary Care & Community Health, doi:10.1177/21501327211041206 (Peer Reviewed)
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Retrospective 92 hospitalized patients not showing significant differences in outcomes based on vitamin D status or supplementation.
risk of death, 70.0% higher, RR 1.70, p = 0.52, treatment 29, control 63, supplementation, unadjusted, RR approximated with OR, excluded in exclusion analyses: unadjusted results with no group details.
risk of mechanical ventilation, 10.0% higher, RR 1.10, p = 0.89, treatment 29, control 63, supplementation, unadjusted, RR approximated with OR, excluded in exclusion analyses: unadjusted results with no group details.
risk of ICU admission, 30.0% higher, RR 1.30, p = 0.61, treatment 29, control 63, supplementation, unadjusted, RR approximated with OR, excluded in exclusion analyses: unadjusted results with no group details.
risk of death, 35.9% lower, RR 0.64, p = 0.74, high D levels (≥20ng/mL) 6 of 77 (7.8%), low D levels (<20ng/mL) 1 of 15 (6.7%), cutoff ≥20ng/mL, odds ratio converted to relative risk, multivariable logistic regression.
risk of mechanical ventilation, 56.9% lower, RR 0.43, p = 0.22, high D levels (≥20ng/mL) 8 of 15 (53.3%), low D levels (<20ng/mL) 4 of 15 (26.7%), cutoff ≥20ng/mL, odds ratio converted to relative risk, multivariable logistic regression.
risk of ICU admission, 13.1% higher, RR 1.13, p = 0.57, high D levels (≥20ng/mL) 54 of 77 (70.1%), low D levels (<20ng/mL) 9 of 15 (60.0%), cutoff ≥20ng/mL, odds ratio converted to relative risk, multivariable logistic regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Pecina et al., 8/27/2021, retrospective, USA, North America, peer-reviewed, 4 authors, dosage not specified.
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