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0 0.5 1 1.5 2+ Case 7% Improvement Relative Risk c19vitamind.com Martineau et al. Vitamin D for COVID-19 META Favors vitamin D Favors control
Martineau, vitamin D meta analysis: 7% fewer cases [p=0.003] https://c19p.org/martineau
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Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
Martineau et al., BMJ 2017, 356, doi:10.1136/bmj.i6583 (meta analysis)
1/1/2017    Source   PDF   Share   Tweet
Meta analysis of 25 RCTs showing vitamin D supplementation was safe and it protected against acute respiratory tract infection overall. Patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit.
Vitamin D supplementation reduced the risk of acute respiratory tract infection among all participants (adjusted odds ratio aOR 0.88 [0.81-0.96], p=0.003.
In subgroup analysis, protective effects were seen in those receiving daily or weekly vitamin D without additional bolus doses (aOR 0.81 [0.72-0.91]) but not in those receiving one or more bolus doses (aOR 0.97 [0.86-1.10]). Among those receiving daily or weekly vitamin D, protective effects were stronger in those with baseline 25-hydroxyvitamin D levels <25 nmol/L (aOR 0.30 [0.17-0.53]) than in those with baseline 25-hydroxyvitamin D levels ≥25 nmol/L (aOR 0.75 [0.60-0.95]).
Currently there are 82 vitamin D for COVID-19 studies, showing 37% [25‑47%] lower mortality, 32% [4‑53%] lower ventilation, 50% [27‑65%] lower ICU admission, 20% [9‑29%] lower hospitalization, and 12% [2‑21%] lower cases.
risk of case, 7.3% lower, RR 0.93, p = 0.003, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Martineau et al., 1/1/2017, peer-reviewed, 25 authors.
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