Karonova, 78 patient vitamin D prophylaxis RCT: 95% fewer symptomatic cases [p=0.002] and 42% fewer cases [p=0.1] https://c19p.org/karonova3
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Vitamin D Intake May Reduce SARS-CoV-2 Infection Morbidity in Health Care Workers
et al., Nutrients, doi:10.3390/nu14030505
Small RCT in Russia with 45 high dose vitamin D patients (50,000IU/wk for 2 wks followed by 5,000IU/day) and 46 low dose patients (2,000IU/day), showing lower cases and lower symptomatic cases with high dose treatment.
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risk of symptomatic case, 94.6% lower, RR 0.05, p = 0.002, treatment 0 of 38 (0.0%), control 9 of 40 (22.5%), NNT 4.4, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
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risk of case, 41.5% lower, RR 0.58, p = 0.10, treatment 10 of 38 (26.3%), control 18 of 40 (45.0%), NNT 5.4.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Karonova et al., 24 Jan 2022, Randomized Controlled Trial, Russia, peer-reviewed, 8 authors.
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