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0 0.5 1 1.5 2+ Ventilation -95% Improvement Relative Risk Ventilation (b) -95% Hospitalization -41% Hospitalization (b) -17% Case -9% Case (b) -25% c19vitamind.com Jolliffe et al. NCT04579640 Vitamin D RCT Prophylaxis Favors vitamin D Favors control
Jolliffe, 4,464 patient vitamin D prophylaxis RCT: 41% higher hospitalization [p=0.16] and 9% more cases [p=0.55] https://c19p.org/jolliffe2
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Vitamin D Supplements for Prevention of Covid-19 or other Acute Respiratory Infections: a Phase 3 Randomized Controlled Trial (CORONAVIT)
Jolliffe et al., medRxiv, doi:10.1101/2022.03.22.22271707 (Preprint)
23 Mar 2022    Source   PDF   Share   Tweet
RCT 5,979 low risk patients (0 COVID-19 deaths) in the UK, showing no significant differences with vitamin D prophylaxis. CORONAVIT. NCT04579640. For more discussion see [reddit.com, twitter.com].
Authors do not provide exact start/end dates (month only) or specify when infections occurred, however based on cases in the UK, most infections may have been closer to the start of the trial when vitamin D levels may still have been relatively low. Reportedly, authors do not plan to analyze this issue, and have declined to allow one of the funders access to the data.
[Villasis-Keever] present an RCT showing conflicting results, 78% lower cases with vitamin D prophylaxis. In comparison, [Villasis-Keever] used a higher dose, the participants had much higher exposure to SARS-CoV-2 patients, and the study was prior to vaccination. In this study, 89% of participants had received a vaccine dose by the end of the study period, and the period overlapped with increasing solar UVB.
risk of mechanical ventilation, 94.7% higher, RR 1.95, p = 1.00, treatment 1 of 1,515 (0.1%), control 1 of 2,949 (0.0%), 3200IU/day.
risk of mechanical ventilation, 94.7% higher, RR 1.95, p = 1.00, treatment 1 of 1,515 (0.1%), control 1 of 2,949 (0.0%), 800IU/day.
risk of hospitalization, 41.1% higher, RR 1.41, p = 0.16, treatment 29 of 1,515 (1.9%), control 40 of 2,949 (1.4%), 3200IU/day.
risk of hospitalization, 16.8% higher, RR 1.17, p = 0.60, treatment 24 of 1,515 (1.6%), control 40 of 2,949 (1.4%), 800IU/day.
risk of case, 8.8% higher, RR 1.09, p = 0.55, treatment 76 of 1,515 (5.0%), control 136 of 2,949 (4.6%), 3200IU/day.
risk of case, 24.5% higher, RR 1.25, p = 0.11, treatment 87 of 1,515 (5.7%), control 136 of 2,949 (4.6%), 800IU/day.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Jolliffe et al., 3/23/2022, Randomized Controlled Trial, United Kingdom, Europe, preprint, median age 60.2, 24 authors, study period December 2020 - June 2021, dosage 3,200IU daily, daily, trial NCT04579640.
Contact: d.a.jolliffe@qmul.ac.uk, a.martineau@qmul.ac.uk.
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