26 August 2021 - Analysis of outcomes based on serum levels
The Association between Vitamin D and Zinc Status and the Progression of Clinical Symptoms among Outpatients Infected with SARS-CoV-2 and Potentially Non-Infected Participants: A Cross-Sectional Study
et al., Nutrients, doi:10.3390/nu13103368 (preprint 8/26/2021) (Peer Reviewed)
Analysis of vitamin D and zinc levels in 53 PCR+ outpatients and 53 matched controls, showing lower zinc levels in COVID-19 patients, and increased risk of cases and symptoms with vitamin D deficiency. There was no significant difference in the use of supplements between cases and controls. IR.ABADANUMS.REC.1399.073.
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odds of symptoms, 90.0% lower, RR 0.10, p < 0.001, high D levels 34, low D levels 10, >30ng/mL vs. <20ng/mL, GEE regression, RR approximated with OR.
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odds of symptoms, 81.0% lower, RR 0.19, p = 0.006, high D levels 34, low D levels 9, 20-30ng/mL vs. <20ng/mL, GEE regression, RR approximated with OR.
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risk of case, 71.7% lower, RR 0.28, p = 0.07, high D levels 34 of 44 (77.3%) cases,
36 of 39 (92.3%) controls, NNT 3.5, case control OR, >30ng/mL vs. <20ng/mL.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. |
Golabi et al., 8/26/2021, retrospective, Iran, Middle East, peer-reviewed, 10 authors.
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