E cacy and safety of vitamin D supplementation in hospitalized COVID-pediatric patients: A randomized controlled trial
Maurizio Aricò, Mehmet Güven, Dr Rinawati Rohsiswatmo, Cipto Mangunkusumo, Guadalupe Miranda-Novales, Zurita-Cruz J Fonseca-Tenorio, Villasís-Keever M López-Alarcón, M Parra-Ortega I, López-Martínez, Jessie Zurita-Cruz, Je Ry Fonseca-Tenorio, Miguel Villasís-Keever, Mardia López-Alarcón, Israel Parra-Ortega, Briceida López-Martínez
Novales G ( ) E cacy and safety of vitamin D supplementation in hospitalized COVID-pediatric patients: A randomized controlled trial.
Ethics statement The studies involving human participants were reviewed and approved by Comité Local de Ética en Investigación number 3603, authorization number R-2020-3603-20. Written informed consent to participate in this study was provided by the participants' legal guardian/next of kin.
Author contributions JZ-C, MV-K, ML-A, and GM-N: study design. JF-T, IP-O, BL-M, and GM-N: collection, analysis, and interpretation of data. JZ-C, GM-N, and MV-K: manuscript preparation and final approval. All the authors have contributed to the article and approved the submitted version of the manuscript.
Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
Agarwal, Rochwerg, Lamontagne, Siemieniuk, Agoritsas et al., A living WHO guideline on drugs for COVID-19, BMJ,
doi:10.1136/bmj.m3379
Banchereau, Steinman, Dendritic cells and the control of immunity, Nature,
doi:10.1038/32588
Castillo, Costa, Barrios, Díaz, Miranda et al., Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, J Steroid Biochem Mol Biol,
doi:10.1016/j.jsbmb.2020.105751
Chiodini, Gatti, Soranna, Merlotti, Mingiano et al., The effect of high-dose parenteral vitamin D3 on COVID-19-related inhospital mortality in critical COVID-19 patients during intensive care unit admission: an observational cohort study, Front Public Health,
doi:10.1038/s41430-021-00984-5
Esposito, Marchetti, Lanari, Caramelli, Fanti et al., COVID-19 management in the pediatric age: consensus document of the COVID-19 working group in paediatrics of the Emilia-Romagna region (RE-CO-Ped), Italy, Int J Environ Res Public Health,
doi:10.3390/ijerph18083919
González-García, Castilla-Peón, Santos, Bustamante, Hibert, COVID-19 incidence and mortality by age strata and comorbidities in Mexico city: a focus in the pediatric population, Front Public Health,
doi:10.1038/nature06175
Holick, Binkley, Bischoff-Ferrari, Gordon, Hanley et al., Evaluation, treatment, and prevention of Vitamin D deficiency: and endocrine society clinical practice guideline, J Clin Endocrinol Metabol,
doi:10.1210/jc.2011-0385
Kalinina, Vitamin D intake may reduce SARS-CoV-2 infection morbidity in health care workers, Nutrients,
doi:10.3390/nu14030505
Kang, Jeong, Suh, Ahn, The impact of the Coronavirus disease-2019 pandemic on childhood obesity and vitamin D status, J Korean Med Sci,
doi:10.3346/jkms.2021.36.e21
Kumar, Rathi, Haq, Wimalawansa, Sharma, Putative roles of vitamin D in modulating immune response and immunopathology associated with COVID-19, Virus Res,
doi:10.1016/j.virusres.2020.198235
Liu, He, Liu, Li, Shi, Children with COVID-19 behaving milder may challenge the public policies: a systematic review and meta-analysis, BMC Pediatr,
doi:10.1186/s12887-020-02316-1
Liu, Sun, Wang, Zhang, Zhao et al., Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis, Int J Infect Dis,
doi:10.1186/s12879-021-06281-7
Meoli, Muggli, Lava, Bianchetti, Agostoni et al., Vitamin D status in adolescents during COVID-19 pandemic: a cross-sectional comparative study, Epidemiol Infect,
doi:10.1017/S0950268821001825
Murai, Fernandes, Sales, Pinto, Goessler et al., Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial, JAMA,
doi:10.1001/jama.2020.26848
Nogues, Ovejero, Pineda-Moncusí, Bouillon, Arenas et al., Calcifediol treatment and COVID-19-related outcomes, J Clin Endocrinol Metab,
doi:10.1210/clinem/dgab405
Noriega, Savelkoul, Vitamin D: a potential mitigation tool for the endemic stage of the COVID-19 pandemic?, Front Public Health,
doi:10.3389/fpubh.2022.888168
Oscanoa, Amado, Vidal, Laird, Ghashut et al., The relationship between the severity and mortality of SARS-CoV-2 infection and 25-hydroxyvitamin D concentration -a metaanalysis, Expert Rev Anti Infect Ther,
doi:10.1101/2021.08.22.21262216
Penna, Amuchastegui, Giarratana, Daniel, Vulcano et al., 1, 25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells, J Immunol,
doi:10.4049/jimmunol.178.1.145
Petrelli, Luciani, Perego, Dognini, Colombelli et al., Therapeutic and prognostic role of vitamin D for COVID-19 infection: a systematic review and meta-analysis of 43 observational studies, J Steroid Biochem Mol Biol,
doi:10.1016/j.jsbmb.2021.105883
Ramirez-Sandoval, Vj, Paz-Cortés, Santillan-Ceron, Hernandez-Jimenez et al., Very low vitamin D levels are a strong independent predictor of mortality in hospitalized patients with severe COVID-19, Arch Med Res,
doi:10.3390/nu13061990
Rastogi, Bhansali, Khare, Suri, Yaddanapudi et al., Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study), Postgrad Med J,
doi:10.1136/postgradmedj-2020-139065
Shah, Varna, Pandya, Saxena, Low vitamin D levels and prognosis in a COVID-19 pediatric population: a systematic review, QJM,
doi:10.1093/qjmed/hcab202
Simon, Hollander, Mcmichael, Evolution of the immune system in humans from infancy to old age, Proc Biol Sci,
doi:10.1098/rspb.2014.3085
Somnath, Biswal, Chandrasekaran, Jagadisan, Bobby et al., Vitamin D supplementation for the prevention of childhood acute respiratory infections: a systematic review of randomised controlled trials, Clin Nutr ESPEN,
doi:10.1017/S000711451500207X
Tessa, Motisi, Marseglia, Cardinale, Licari et al., Use of remdesivir in children with COVID-19 infection: a quick narrative review, Acta Biomed,
doi:10.23750/abm.v92iS7.12396
Urashima, Segawa, Okazaki, Kuriharam, Wada et al., Reduced primary care respiratory infection visits following pregnancy and infancy vitamin D supplementation: a randomised controlled trial, Am J Clin Nutr,
doi:10.1111/apa.12819
Van Den Ouweland, Beijers, Demacker, Van Daal, Measurement of 25-OH-vitamin D in human serum using liquid chromatography tandemmass spectrometry with comparison to radioimmunoassay and automated immunoassay, J Chromatogr B Analyt Technol Life Sci,
doi:10.1016/j.jchromb.2010.03.035
Vecchio, Treatment of children with COVID-19: update of the Italian society of pediatric infectious diseases position paper, Ital J Pediatr,
doi:10.1186/s13052-021-01132-2
Veldman, Cantorna, Deluca, Expression of 1,25-dihydroxyvitamin D3 receptor in the immune system, Arch Biochem Biophys,
doi:10.1006/abbi.1999.1605
Venturini, Montagnani, Garazzino, Donà, Pierantoni et al., None
Wang, Nestel, Bourdeau, Nagai, Wang et al., A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections, Epidemiol Infect,
doi:10.1017/S0950268809002404
Wang, Zhao, Tang, Wang, Shi et al., Potentially effective drugs for the treatment of COVID-19 or MIS-C in children: a systematic review, Eur J Pediatr,
doi:10.1007/s00431-022-04388-w
Wrapp, Wang, Corbett, Goldsmith, Hsieh et al., Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation, Science,
doi:10.1126/science.abb2507