Does Serum Vitamin D Level Affect COVID-19 Infection and Its Severity? A Case-Control Study

Vitamin D study #32 of 131 Meta Analysis

10/13 Analysis of outcomes based on serum levels

Ye et al., Journal of the American College of Nutrition, doi:10.1080/07315724.2020.182600 (Peer Reviewed)
Does Serum Vitamin D Level Affect COVID-19 Infection and Its Severity? A Case-Control Study

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Case control study in China comparing 62 patients with 80 healthy controls showing vitamin D deficiency is a risk factor for COVID-19, especially for severe/critical cases.

Ye et al., 10/13/2020, retrospective, China, Asia, peer-reviewed, 18 authors.

risk of severe/critical COVID-19, 93.4% lower, RR 0.07, p = 0.03, high D levels 2 of 36 (5.6%), low D levels 8 of 26 (30.8%), adjusted per study, >50nmol/L.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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