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Vitamin D study #40 of 96
11/9 Analysis of outcomes based on serum levels
Walk et al., medRxiv, doi:10.1101/2020.11.07.20227512 (Preprint)
Vitamin D - contrary to vitamin K - does not associate with clinical outcome in hospitalized COVID-19 patients
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Small retrospective study of 135 patients not finding a significant difference in vitamin D status. Patients with good outcomes had a median of 45.0 nmol/L versus 37.7 nmol/L for bad outcomes, p = 0.85.
Authors found that vitamin D sufficient persons had accelerated elastic fiber degradation, they hypothesize pro-calcification effects during COVID-19 and that vitamin K might compensate for this.

Walk et al., 11/9/2020, retrospective, Netherlands, Europe, preprint, 5 authors.
risk of combined intubation/death, 0.4% higher, RR 1.00, p = 1.00, high D levels 48 of 110 (43.6%), low D levels 10 of 23 (43.5%), >25nmol/L.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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