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Vitamin D study #42 of 126   Meta Analysis
11/9 Analysis of outcomes based on serum levels
Walk et al., medRxiv, doi:10.1101/2020.11.07.20227512 (Preprint)
Vitamin D - contrary to vitamin K - does not associate with clinical outcome in hospitalized COVID-19 patients
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Small retrospective study of 135 patients not finding a significant difference in vitamin D status. Patients with good outcomes had a median of 45.0 nmol/L versus 37.7 nmol/L for bad outcomes, p = 0.85.
Authors found that vitamin D sufficient persons had accelerated elastic fiber degradation, they hypothesize pro-calcification effects during COVID-19 and that vitamin K might compensate for this.

Walk et al., 11/9/2020, retrospective, Netherlands, Europe, preprint, 5 authors.
risk of combined intubation/death, 0.4% higher, RR 1.00, p = 1.00, high D levels 48 of 110 (43.6%), low D levels 10 of 23 (43.5%), >25nmol/L.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 126 studies   Meta Analysis
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