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Vitamin D study #65 of 96
1/18 Pre-Exposure Prophylaxis study (treated before exposed to the virus)
Vasheghani et al., Research Square, doi: 10.21203/ (Preprint)
The Association of 25 (OH) Vitamin D Levels and Severity and Outcome of COVID-19: A Cross-sectional Study
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Retrospective 508 hospitalized COVID-19 patients in Iran showing lower mortality with vitamin D supplementation, and an association between low vitamin D levels and disease severity, ICU admission, and increased mortality. Details of supplementation are not provided.

Vasheghani et al., 1/18/2021, retrospective, Iran, Middle East, preprint, 5 authors, dosage not specified.
risk of death, 30.4% lower, RR 0.70, p = 0.45, treatment 7 of 88 (8.0%), control 48 of 420 (11.4%), vitamin D supplementation.
risk of ICU admission, 63.8% lower, RR 0.36, p = 0.009, treatment 13 of 185 (7.0%), control 53 of 323 (16.4%), adjusted per study, vitamin D levels >30ng/mL.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
Details of all 96 studies
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