Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All vitamin D studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Case 98% Improvement Relative Risk Vitamin D  van Helmond et al.  Prophylaxis Does vitamin D reduce COVID-19 infections? Prospective study of 3,082 patients in the USA (Oct 2020 - Jan 2021) Fewer cases with vitamin D (not stat. sig., p=0.069) c19early.org van Helmond et al., Nutrients, September 2022 Favors vitamin D Favors control

Vitamin D3 Supplementation at 5000 IU Daily for the Prevention of Influenza-like Illness in Healthcare Workers: A Pragmatic Randomized Clinical Trial

van Helmond et al., Nutrients, doi:10.3390/nu15010180 (date from preprint), NCT04596657
Sep 2022  
  Post
  Facebook
Share
  Source   PDF   All   Meta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 7 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
Prospective prophylaxis trial with 255 healthcare workers taking vitamin D and 2,827 controls, showing significantly lower influenza-like illness with treatment, and lower COVID-19 cases, without statistical significance. While the intervention and control groups were initially randomized, exclusions were only processed in the treatment arm.
This is the 96th of 120 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 226 sextillion).
29 studies are RCTs, which show efficacy with p=0.0000035.
risk of case, 97.5% lower, RR 0.02, p = 0.07, treatment 0 of 255 (0.0%), control 36 of 2,827 (1.3%), NNT 79, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
van Helmond et al., 17 Sep 2022, prospective, USA, peer-reviewed, 14 authors, study period 27 October, 2020 - 31 January, 2021, dosage 5,000IU daily, trial NCT04596657 (history). Contact: mitrev-ludmil@cooperhealth.edu, vanhelmond-noud@cooperhealth.edu.
This PaperVitamin DAll
Vitamin D3 Supplementation at 5000 IU Daily for the Prevention of Influenza-like Illness in Healthcare Workers: A Pragmatic Randomized Clinical Trial
Noud Van Helmond, Tracy L Brobyn, Patrick J Lariccia, Teresa Cafaro, Krystal Hunter, Satyajeet Roy, Brigid Bandomer, Kevin Q Ng, Helen Goldstein, Ludmil V Mitrev, Alan Tsai, Denise Thwing, Mary Ann Maag, Myung K Chung
Nutrients, doi:10.3390/nu15010180
Vitamin D supplementation has been shown to reduce the incidence of acute respiratory infections in populations at risk. The COVID-19 pandemic has highlighted the importance of preventing viral infections in healthcare workers. The aim of this study was to assess the hypothesis that vitamin D3 supplementation at 5000 IU daily reduces influenza-like illness (ILI), including COVID-19, in healthcare workers. We conducted a prospective, controlled trial at a tertiary university hospital. A random group of healthcare workers was invited to receive 5000 IU daily vitamin D3 supplementation for nine months, while other random healthcare system workers served as controls. All healthcare workers were required to self-monitor and report to employee health for COVID-19 testing when experiencing symptoms of ILI. COVID-19 test results were retrieved. Incidence rates were compared between the vitamin D and control groups. Workers in the intervention group were included in the analysis if they completed at least 2 months of supplementation to ensure adequate vitamin D levels. The primary analysis compared the incidence rate of all ILI, while secondary analyses examined incidence rates of COVID-19 ILI and non-COVID-19 ILI. Between October 2020 and November 2021, 255 healthcare workers (age 47 ± 12 years, 199 women) completed at least two months of vitamin D3 supplementation. The control group consisted of 2827 workers. Vitamin D3 5000 IU supplementation was associated with a lower risk of ILI (incidence rate difference: −1.7 × 10 −4 /person-day, 95%-CI: −3.0 × 10 −4 to −3.3 × 10 −5 /person-day, p = 0.015) and a lower incidence rate for non-COVID-19 ILI (incidence rate difference: −1.3 × 10 −4 /personday, 95%-CI −2.5 × 10 −4 to −7.1 × 10 −6 /person-day, p = 0.038). COVID-19 ILI incidence was not statistically different (incidence rate difference: −4.2 × 10 −5 /person-day, 95%-CI: −10.0 × 10 −5 to 1.5 × 10 −5 /person-day, p = 0.152). Daily supplementation with 5000 IU vitamin D3 reduces influenzalike illness in healthcare workers.
Supplementary Materials: The following supporting information can be downloaded at: https:// www.mdpi.com/article/10.3390/nu15010180/s1, Table S1 . CONSORT Checklist, Table S2 . Adverse events (AE) and relatedness among intervention group during 9-month study period
References
Adamson, Cockayne, Puffer, Torgerson, Review of randomised trials using the post-randomised consent (Zelen's) design, Contemp. Clin. Trials, doi:10.1016/j.cct.2005.11.003
Aloia, Patel, Dimaano, Li-Ng, Talwar et al., Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration, Am. J. Clin. Nutr, doi:10.1093/ajcn/87.6.1952
Austin, Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensityscore matched samples, Stat. Med, doi:10.1002/sim.3697
Baden, El Sahly, Essink, Kotloff, Frey et al., Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine, N. Engl. J. Med, doi:10.1056/NEJMoa2035389
Bergman, Lindh, Björkhem-Bergman, Lindh, Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, PLoS ONE, doi:10.1371/journal.pone.0065835
Castillo, Entrenas Costa, Vaquero Barrios, Alcalá Díaz, López Miranda et al., Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, J. Steroid Biochem. Mol. Biol, doi:10.1016/j.jsbmb.2020.105751
Clinic, Hypercalcemia
Cohen, Statistical Power Analysis for the Behavioral Sciences
Ekwaru, Zwicker, Holick, Giovannucci, Veugelers, The importance of body weight for the dose response relationship of oral vitamin D supplementation and serum 25-hydroxyvitamin D in healthy volunteers, PLoS ONE, doi:10.1371/journal.pone.0111265
Gabbard, Pajewski, Callahan, Dharod, Foley et al., Advance care planning for vulnerable older adults within an Accountable Care Organization: Study protocol for the IMPACT randomised controlled trial, BMJ Open, doi:10.1136/bmjopen-2019-032732
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths, Nutrients, doi:10.3390/nu12040988
Hardcastle, Chamberlain, Robinson, Moss, Amar et al., Randomised controlled trial of faecal-occult-blood screening for colorectal cancer, Lancet, doi:10.1016/S0140-6736(96)03386-7
Harris, Taylor, Minor, Elliott, Fernandez et al., The REDCap consortium: Building an international community of software platform partners, J. Biomed. Inf
Harris, Taylor, Thielke, Payne, Gonzalez et al., Research electronic data capture (REDCap)-A metadatadriven methodology and workflow process for providing translational research informatics support, J. Biomed. Inf, doi:10.1016/j.jbi.2008.08.010
Hathcock, Shao, Vieth, Heaney, Risk assessment for vitamin D, Am. J. Clin. Nutr, doi:10.1093/ajcn/85.1.6
Hoang, Shaw, Fang, Han, Possible application of high-dose vitamin C in the prevention and therapy of coronavirus infection, J. Glob. Antimicrob. Resist, doi:10.1016/j.jgar.2020.09.025
Holick, Vitamin D Is Not as Toxic as Was Once Thought: A Historical and an Up-to-Date Perspective, Mayo Clin. Proc, doi:10.1016/j.mayocp.2015.03.015
House, Knapp, Informed consent. Trials that use Zelen's procedure should be acceptable, BMJ
Jolliffe, Camargo, Jr, Sluyter, Aglipay et al., Vitamin D supplementation to prevent acute respiratory infections: A systematic review and meta-analysis of aggregate data from randomised controlled trials, Lancet Diabetes Endocrinol, doi:10.1016/S2213-8587(21)00051-6
Jolliffe, Holt, Greenig, Talaei, Perdek et al., Vitamin D Supplements for Prevention of COVID-19 or other Acute Respiratory Infections: A Phase 3 Randomized Controlled Trial (CORONAVIT), medRxiv, doi:10.1101/2022.03.22.22271707
Keech, Beardsworth, The impact of influenza on working days lost: A review of the literature, PharmacoEconomics, doi:10.2165/00019053-200826110-00004
Kimball, Mirhosseini, Holick, Evaluation of vitamin D3 intakes up to 15,000 international units/day and serum 25-hydroxyvitamin D concentrations up to 300 nmol/L on calcium metabolism in a community setting, Derm.-Endocrinol, doi:10.1080/19381980.2017.1300213
Kinman, Grant, Presenteeism during the COVID-19 pandemic: Risks and solutions, Occup. Med, doi:10.1093/occmed/kqaa193
Leaf, Ginde, Vitamin D3 to Treat COVID-19: Different Disease, Same Answer, JAMA, doi:10.1001/jama.2020.26850
Li, Kong, Wei, Chen, Liu et al., 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system, J. Clin. Investig, doi:10.1172/JCI0215219
Loef, Van Baarle, Van Der Beek, Sanders, Bruijning-Verhagen et al., Shift Work and Respiratory Infections in Health-Care Workers, Am. J. Epidemiol, doi:10.1093/aje/kwy258
Martineau, Jolliffe, Hooper, Greenberg, Aloia et al., Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data, BMJ, doi:10.1136/bmj.i6583
Mascha, Schober, Schefold, Stueber, Luedi, Staffing with Disease-Based Epidemiologic Indices May Reduce Shortage of Intensive Care Unit Staff During the COVID-19 Pandemic, Anesth. Analg, doi:10.1213/ANE.0000000000004849
Murai, Fernandes, Sales, Pinto, Goessler et al., Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients with Moderate to Severe COVID-19: A Randomized Clinical Trial, JAMA, doi:10.1001/jama.2020.26848
Nguyen, Drew, Graham, Joshi, Guo et al., Risk of COVID-19 among front-line health-care workers and the general community: A prospective cohort study, Lancet Public Health, doi:10.1016/S2468-2667(20)30164-X
Pepper, Judd, Nanes, Tangpricha, Evaluation of vitamin D repletion regimens to correct vitamin D status in adults, Endocr. Pract, doi:10.4158/EP.15.2.95
Polack, Thomas, Kitchin, Absalon, Gurtman et al., Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine, N. Engl. J. Med, doi:10.1056/NEJMoa2034577
Rastogi, Bhansali, Khare, Suri, Yaddanapudi et al., Short term, high-dose vitamin D supplementation for COVID-19 disease: A randomised, placebo-controlled, study (SHADE study), Postgrad. Med. J, doi:10.1136/postgradmedj-2020-139065
Sadoff, Gray, Vandebosch, Cárdenas, Shukarev et al., Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against COVID-19, N. Engl. J. Med, doi:10.1056/NEJMoa2101544
Sahai, Khurshid, Statistics in Epidemiology: Methods, Techniques, and Applications
Schulz, Altman, Moher, Consort, statement: Updated guidelines for reporting parallel group randomised trials, BMJ, doi:10.1136/bmj.c332
Shang, Ye, Shi, Wan, Luo et al., Structural basis of receptor recognition by SARS-CoV-2, Nature, doi:10.1038/s41586-020-2179-y
Sinopoli, Caminada, Isonne, Maria Mercedes, Baccolini, What Are the Effects of Vitamin A Oral Supplementation in the Prevention and Management of Viral Infections? A Systematic Review of Randomized Clinical Trials, Nutrients, doi:10.3390/nu14194081
Stuart, Lee, Leacy, Prognostic score-based balance measures can be a useful diagnostic for propensity score methods in comparative effectiveness research, J. Clin. Epidemiol, doi:10.1016/j.jclinepi.2013.01.013
Torgerson, Roland, What is Zelen's design?, BMJ, doi:10.1136/bmj.316.7131.606
Torgerson, The use of Zelen's design in randomised trials, BJOG, doi:10.1111/j.1471-0528.2004.00033.x
Tsai, Zhou, Kim, The burden of influenza-like illness in the US workforce, Occup. Med, doi:10.1093/occmed/kqu022
Vieth, Vitamin D toxicity, policy, and science, J. Bone Miner. Res, doi:10.1359/jbmr.07s221
Villasis-Keever, López-Alarcón, Miranda-Novales, Zurita-Cruz, Barrada-Vázquez et al., Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial, Arch. Med. Res, doi:10.1016/j.arcmed.2022.04.003
Widera, Chang, Chen, Presenteeism: A public health hazard, J. Gen. Intern. Med, doi:10.1007/s11606-010-1422-x
Zelen, A new design for randomized clinical trials, N. Engl. J. Med, doi:10.1056/NEJM197905313002203
Çelebi, Pişkin, Çelik Bekleviç, Altunay, Salcı Keleş et al., Specific risk factors for SARS-CoV-2 transmission among health care workers in a university hospital, Am. J. Infect. Control
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit