Serum Vitamin D levels are associated with increased COVID-19 severity markers and mortality independent of visceral adiposity

Vitamin D study #92 of 131 Meta Analysis

3/14 Analysis of outcomes based on serum levels

Vanegas-Cedillo, medRxiv, doi:10.1101/2021.03.12.21253490 (Preprint)
Serum Vitamin D levels are associated with increased COVID-19 severity markers and mortality independent of visceral adiposity

Source PDF Share Tweet

Retrospective 551 moderate to severe COVID-19 patients in Mexico showing vitamin D ≤12ng/mL independently associated with COVID-19 mortality. No association was found between vitamin D levels and the need for intubation. Vitamin D deficiency was more prevalent in women and patients with type 2 diabetes.

Vanegas-Cedillo et al., 3/14/2021, retrospective, Mexico, North America, preprint, 15 authors.

risk of death, 52.6% lower, RR 0.47, p = 0.006, high D levels 95 of 494 (19.2%), low D levels 21 of 57 (36.8%), adjusted per study, >12ng/mL.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 131 studies Meta Analysis

Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. Treatment protocols for physicians are available from the FLCCC.

Submit