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Vitamin D study #87 of 109
3/14 Analysis of outcomes based on serum levels
Vanegas-Cedillo, medRxiv, doi:10.1101/2021.03.12.21253490 (Preprint)
Serum Vitamin D levels are associated with increased COVID-19 severity markers and mortality independent of visceral adiposity
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Retrospective 551 moderate to severe COVID-19 patients in Mexico showing vitamin D ≤12ng/mL independently associated with COVID-19 mortality. No association was found between vitamin D levels and the need for intubation. Vitamin D deficiency was more prevalent in women and patients with type 2 diabetes.

Vanegas-Cedillo et al., 3/14/2021, retrospective, Mexico, North America, preprint, 15 authors.
risk of death, 52.6% lower, RR 0.47, p = 0.006, high D levels 95 of 494 (19.2%), low D levels 21 of 57 (36.8%), adjusted per study, >12ng/mL.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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