Torres: Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D

Torres, 85 patient vitamin D late treatment RCT: 28% lower ARDS [p=0.74] and 31% shorter hospitalization https://c19p.org/torres

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Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D

Torres et al., Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.112965

14 Apr 2022 Source PDF Share Tweet

RCT comparing 41 patients treated with 10,000IU/day cholecalciferol and 44 treated with 2,000IU/day in Spain, showing significantly shorter hospitalization for ARDS patients with the higher dose. There was also an increase of anti-inflammatory cytokine IL-10 and higher levels of CD4+ T cells. Cytotoxic response against pseudotyped SARS-CoV-2 infected cells was over 4-fold higher in patients receiving the higher dose.

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risk of death, 7.3% higher, RR 1.07, p = 1.00, treatment 1 of 41 (2.4%), control 1 of 44 (2.3%).

risk of ICU admission, 57.1% lower, RR 0.43, p = 0.44, treatment 2 of 41 (4.9%), control 5 of 44 (11.4%), NNT 15.

risk of ARDS, 28.5% lower, RR 0.72, p = 0.74, treatment 4 of 41 (9.8%), control 6 of 44 (13.6%), NNT 26.

hospitalization time, 31.2% lower, relative time 0.69, treatment 41, control 44.

hospitalization time, 72.6% lower, relative time 0.27, p = 0.04, ARDS patients.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Torres et al., 14 Apr 2022, Single Blind Randomized Controlled Trial, Spain, peer-reviewed, median age 65.0, 51 authors, study period June 2020 - March 2021, average treatment delay 7.0 days, dosage 10,000IU days 1-14.

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This Paper Vitamin D All

Late treatment
is less effective

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