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Vitamin D study #6 of 109
6/10 Late treatment study
Tan et al., Nutrition, doi:10.1016/j.nut.2020.111017 (Peer Reviewed)
Cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on progression to severe outcome in older COVID-19 patients
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Observational study of 43 patients >= 50 years old, with 17 patients receiving vitamin D, magnesium, and vitamin B12 (DMB); and 26 control patients, showing a significantly lower need for oxygen therapy and ICU admission with treatment.
DMB exposure was associated with odds ratios of 0.13 [0.03–0.59] and 0.20 [0.04–0.93] for oxygen therapy and/or intensive care support on univariate and multivariate analyses respectively.

Tan et al., 6/10/2020, retrospective, Singapore, Asia, peer-reviewed, 14 authors, dosage 1,000IU daily.
risk of oxygen therapy, 80.5% lower, RR 0.20, p = 0.04, treatment 3 of 17 (17.6%), control 16 of 26 (61.5%), adjusted per study.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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