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Vitamin D Status and COVID-19 Clinical Outcomes in Hospitalized Patients

Szeto et al., Endocrine Research, doi:10.1080/07435800.2020.1867162

Dec 2020

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Vitamin D for COVID-19

8th treatment shown to reduce risk in October 2020

^*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.

Lower risk for mortality, ICU admission, hospitalization, progression, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,100+ studies for 60+ treatments. c19early.org

Retrospective 93 hospitalized patients with vitamin D levels 1-365 days before admission, not showing significant differences with vitamin D deficiency or vitamin D levels. Vitamin D levels may vary significantly throughout the year creating a major cofounder that authors do not adjust for.

This is the 34th of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).

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risk of death, 5.6% higher, RR 1.06, p = 1.00, high D levels 14 of 58 (24.1%), low D levels 8 of 35 (22.9%).

risk of mechanical ventilation, 39.7% lower, RR 0.60, p = 0.21, high D levels 10 of 58 (17.2%), low D levels 10 of 35 (28.6%), NNT 8.8.

risk of no hospital discharge, 26.7% higher, RR 1.27, p = 0.50, high D levels 21 of 58 (36.2%), low D levels 10 of 35 (28.6%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Szeto et al., 30 Dec 2020, retrospective, USA, peer-reviewed, 7 authors.

This Paper Vitamin D All

Vitamin D Status and COVID-19 Clinical Outcomes in Hospitalized Patients

Betsy Szeto, Jason E Zucker, Elijah D Lasota, Mishaela R Rubin, Marcella D Walker, Michael T Yin, Adi Cohen

Endocrine Research, doi:10.1080/07435800.2020.1867162

Context: Populations severely affected by COVID-19 are also at risk for vitamin D deficiency. Common risk factors include older age, chronic illness, obesity, and non-Caucasian race. Vitamin D deficiency has been associated with risk for respiratory infections and failure, susceptibility and response to therapy for enveloped virus infection, and immune-mediated inflammatory reaction. Objective: To test the hypothesis that 25-hydroxyvitamin D[25(OH)D] deficiency is a risk factor for severity of COVID-19 respiratory and inflammatory complications. Design: We examined the relationship between prehospitalization 25(OH)D levels (obtained 1-365 days prior to admission) and COVID-19 clinical outcomes in 700 COVID-19 positive hospitalized patients.

Disclosure Statement The authors have nothing to disclose.

References

Abrishami, Dalili, Mohammadi, Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study, Eur J Nutr, doi:10.1007/s00394-020-02411-0

Alipio, Vitamin D supplementation could possibly improve clinical outcomes of patients infected with Coronavirus

Altieri, Cavalier, Bhattoa, Vitamin D testing: advantages and limits of the current assays, Eur J Clin Nutr, doi:10.1038/s41430-019-0553-3

Argenziano, Bruce, Slater, Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series, BMJ, doi:10.1136/bmj.m1996

Baktash, Hosack, Patel, Vitamin D status and outcomes for hospitalised older patients with COVID-19, Postgrad Med J, doi:10.1136/postgradmedj-2020-138712

Beard, Bearden, Striker, Vitamin D and the anti-viral state, J Clin Virol, doi:10.1016/j.jcv.2010.12.006

Berry, Hesketh, Power, Hypponen, Vitamin D status has a linear association with seasonal infections and lung function in British adults, Br J Nutr, doi:10.1017/S0007114511001991

Braun, Chang, Mahadevappa, Association of low serum 25-hydroxyvitamin D levels and mortality in the critically ill, Crit Care Med, doi:10.1097/CCM.0b013e318206ccdf

Chen, Wu, Chen, Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study, BMJ, doi:10.1136/bmj.m1091

Daneshkhah, Agrawal, Eshein, Subramanian, Roy et al., The possible role of vitamin D in suppressing cytokine storm and associated mortality in COVID-19 patients

Forrest, Stuhldreher, Prevalence and correlates of vitamin D deficiency in US adults, Nutr Res, doi:10.1016/j.nutres.2010.12.001

Gennari, Vitamin D deficiency is independently associated with COVID-19 severity and mortality

Ginde, Mansbach, Camargo, Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National health and nutrition examination survey, Arch Intern Med, doi:10.1001/archinternmed.2008.560

Gloth Fm 3 Rd, Gundberg, Hollis, Haddad, Jr et al., Vitamin D deficiency in homebound elderly persons, JAMA, doi:10.1001/jama.1995.03530210037027

Greiller, Martineau, Modulation of the immune response to respiratory viruses by vitamin D, Nutrients, doi:10.3390/nu7064240

Hastie, Mackay, Ho, Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes Metab Syndr, doi:10.1016/j.dsx.2020.04.050

Henrina, Lim, Pranata, COVID-19 and misinformation: how an infodemic fuelled the prominence of vitamin D, Br J Nutr, doi:10.1017/S0007114520002950

Hewison, Antibacterial effects of vitamin D, Nat Rev Endocrinol, doi:10.1038/nrendo.2010.226

Holick, Vitamin D status: measurement, interpretation, and clinical application, Ann Epidemiol, doi:10.1016/j.annepidem.2007.12.001

Huang, Zhu, Xue, Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study, PLoS Negl Trop Dis, doi:10.1371/journal.pntd.0008280

Jassil, Sharma, Bikle, Wang, Vitamin D binding protein and 25-Hydroxyvitamin D levels: emerging clinical applications, Endocr Pract, doi:10.4158/EP161604.RA

Karatekin, Kaya, Salihoglu, Balci, Nuhoglu, Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers, Eur J Clin Nutr, doi:10.1038/sj.ejcn.1602960

Kempker, Tangpricha, Ziegler, Martin, Vitamin D in sepsis: from basic science to clinical impact, Crit Care, doi:10.1186/cc11252

Killerby, Link-Gelles, Haight, Characteristics associated with hospitalization among patients with COVID-19 -metropolitan Atlanta, Georgia, March, MMWR Morb Mortal Wkly Rep, doi:10.15585/mmwr.mm6925e1external

Kim, Bostwick, Social vulnerability and racial inequality in COVID-19 deaths in Chicago, Health Educ Behav, doi:10.1177/1090198120929677

Laaksi, Ruohola, Tuohimaa, An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young finnish men, Am J Clin Nutr, doi:10.1093/ajcn/86.3.714

Laird, Rhodes, Kenny, Vitamin D and Inflammation: potential implications for severity of Covid-19, Ir Med J

Madden, Feldman, Chun, Critically Ill children have low vitamin D-binding protein, influencing bioavailability of vitamin D, Ann Am Thorac Soc, doi:10.1513/AnnalsATS.201503-160OC

Martineau, Jolliffe, Hooper, Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ, doi:10.1136/bmj.i6583

Meltzer, Best, Zhang, Vokes, Arora et al., Association of vitamin d deficiency and treatment with COVID-19 incidence

Millett, Jones, Benkeser, Assessing differential impacts of COVID-19 on black communities, Ann Epidemiol, doi:10.1016/j.annepidem.2020.05.003

O'connor, Exploring links between Coronavirus and vitamin D, The New York Times

Olliver, Spelmink, Hiew, Meyer-Hoffert, Henriques-Normark et al., Immunomodulatory effects of vitamin D on innate and adaptive immune responses to Streptococcus pneumoniae, J Infect Dis, doi:10.1093/infdis/jit355

Pizzini, Aichner, Sahanic, Impact of vitamin d deficiency on COVID-19-A prospective analysis from the CovILD registry, Nutrients, doi:10.3390/nu12092775

Raharusuna, Priambada, Budiarti, Agung, Budi, Patterns of COVID-19 mortality and vitamin D: an Indonesian study

Thickett, Moromizato, Litonjua, Association between prehospital vitamin D status and incident acute respiratory failure in critically ill patients: a retrospective cohort study, BMJ Open Respir Res, doi:10.1136/bmjresp-2014-000074

Umhau, Casting sunlight on an epidemic -is vitamin D a critical host factor to prevent COVID-19? MedPage Today

Vanherwegen, Gysemans, Mathieu, Regulation of immune function by vitamin d and its use in diseases of immunity, Endocrinol Metab Clin North Am, doi:10.1016/j.ecl.2017.07.010

Wayse, Yousafzai, Mogale, Filteau, Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5, Eur J Clin Nutr, doi:10.1038/sj.ejcn.1601845

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