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Vitamin D study #157   Meta Analysis
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Moderate/severe case 79% Imp. Relative Risk, 95% CI Case 60% Sinaci: Impact of vitamin D on the course of COVID-19 during pre.. c19vitamind.com/sinaci.html Favors vitamin D Favors control
8/11 Analysis of outcomes based on serum levels
Sinaci et al., The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2021.105964 (Peer Reviewed)
Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study
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Retrospective 159 COVID-19+ pregnant women in Turkey and 332 healthy pregnant controls, showing significantly lower vitamin D levels in COVID-19+ patients. 23% of COVID-19 patients where on vitamin D supplementation, while none of the 7 severe cases were on supplementation.
risk of moderate/severe case, 79.5% lower, RR 0.21, p < 0.001, high D levels 8 of 100 (8.0%), low D levels 23 of 59 (39.0%), >10ng/mL.
risk of case, 59.9% lower, RR 0.40, p < 0.001, high D levels 100 of 397 (25.2%), low D levels 59 of 94 (62.8%), >10ng/mL.
Sinaci et al., 8/11/2021, retrospective, Turkey, Europe, peer-reviewed, 10 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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