Retrospective 20 ICU patients treated with vitamin D in the UAE, and 25 matched controls, showing significantly shorter ICU stay with treatment. Lower proinflammatory cytokines were associated with lower severity markers. Authors also perform a PBMC In Vitro study, with both the clinical and in vitro studies showing vitamin D attenuated major proinflammatory signaling pathways.
ICU time, 35.7% lower, relative time 0.64, p = 0.01, treatment 20, control 25.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sharif-Askari et al., 24 Aug 2022, retrospective, USA, peer-reviewed, 10 authors, dosage 50,000IU days 1, 8, 15.