Severe COVID-19 patients have severe vitamin D deficiency in Northeast Mexico
Manuel Enrique De La O-Cavazos, Edgar Paolo Rodríguez Vidales, Denise Garza Carrillo, Ana María Salinas Martínez, Olivia Abigail Robles Rodríguez, Roberto Montes De Oca Luna, Consuelo Treviño Garza, Alma Rosa Marroquín Escamilla
Nutrición Hospitalaria, doi:10.20960/nh.03731
Objective: the association between vitamin D and COVID-19 severity is not consistent. We compared prevalences and analyzed the association between vitamin D deficiency and COVID-19 severity in Northeast Mexico.
Methods : this was a cross-sectional study with individuals consecutively included at a referral diagnostic center during March-September 2020 (n = 181). Concurrently, every patient admitted to intensive care was also consecutively included (n = 116). Serum 25(OH)D < 20 ng/mL was considered vitamin D deficiency. Descriptive, ANOVA, and multivariate ordinal regression analyses were performed. Results: vitamin D deficiency prevalence was 63.8 % (95 % CI, 54.7, 72.0) in severe COVID-19; 25.6 % (95 % CI, 17.4, 36.0) in mild COVID-19; and 42.4 % (95 % CI, 33.2, 52.3) in non-diseased individuals. Vitamin D deficiency increased 5 times the odds of severe COVID-19 (95 % CI, 1.1, 24.3), independently of sex, age, body mass index, and inflammatory markers. Conclusions: this study is the first report of vitamin D deficiency in Northeast Mexico. Vitamin D deficiency was associated with COVID-19 severity.
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