Review of the use of calcifediol for COVID-19. Authors note several advantages of calcifediol vs. cholecalciferol: calcifediol induces a more rapid increase in circulating 250HD; calcifediol is more potent than cholecalciferol; calcifediol has a higher rate of intestinal absorption; and calcifediol has a linear dose-response curve, independent of initial serum levels.
Authors note that the available data strongly and consistently suggest that treatment with calcifediol can reduce the severity of COVID-19; and that calcifediol is cost-effective and widely available, without significant adverse effects. Authors propose to use calcifediol for the rapid correction of vitamin D deficiency in all patients in the early stages of COVID-19.
Quesada-Gomez et al., 6/29/2022, peer-reviewed, 7 authors.
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