Low vitamin D levels and increased neutrophil in patients admitted at ICU with COVID-19

Vitamin D study #111 of 131 Meta Analysis

5/31 Analysis of outcomes based on serum levels

Pimental et al., Clinical Nutrition ESPEN, doi:10.1016/j.clnesp.2021.05.021 (Peer Reviewed)
Low vitamin D levels and increased neutrophil in patients admitted at ICU with COVID-19

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Retrospective 25 ICU patients in Brazil, showing vitamin D deficiency associated with higher neutrophil-lymphocyte ratio. There appears to be a typo in the mortality percentage for vitamin D deficiency (20% is not valid for the group size of 8).

Pimental et al., 5/31/2021, retrospective, Brazil, South America, peer-reviewed, 3 authors.

risk of death, 29.4% lower, RR 0.71, p = 1.00, high D levels 3 of 17 (17.6%), low D levels 2 of 8 (25.0%), >20ng/mL.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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