Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised with COVID-19 are associated with greater disease severity: results of a local audit of practice

Vitamin D study #10 of 131 Meta Analysis

6/30 Analysis of outcomes based on serum levels

Panagiotou et al., medRxiv, doi:10.1101/2020.06.21.20136903 (Preprint)
Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised with COVID-19 are associated with greater disease severity: results of a local audit of practice

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Retrospective analysis 134 hospitalized patients. 19% of ICU patients had 25(OH)D levels > 50 nmol/L vs. 39.1% of non-ICU patients, p=0.02

Panagiotou et al., 6/30/2020, retrospective, United Kingdom, Europe, preprint, 12 authors.

risk of ICU admission, 52.0% lower, RR 0.48, p = 0.02, high D levels 8 of 44 (18.2%), low D levels 34 of 90 (37.8%), >50nmol/L.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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