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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ ICU admission 52% Improvement Relative Risk Vitamin D for COVID-19  Panagiotou et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 134 patients in the United Kingdom Lower ICU admission with higher vitamin D levels (p=0.02) c19early.org Panagiotou et al., medRxiv, June 2020 Favors vitamin D Favors control

Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised with COVID-19 are associated with greater disease severity: results of a local audit of practice

Panagiotou et al., medRxiv, doi:10.1101/2020.06.21.20136903
Jun 2020  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 7 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
Retrospective analysis 134 hospitalized patients. 19% of ICU patients had 25(OH)D levels > 50 nmol/L vs. 39.1% of non-ICU patients, p=0.02
This is the 4th of 194 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 2470 vigintillion).
risk of ICU admission, 52.0% lower, RR 0.48, p = 0.02, high D levels 8 of 44 (18.2%), low D levels 34 of 90 (37.8%), NNT 5.1, >50nmol/L.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Panagiotou et al., 30 Jun 2020, retrospective, United Kingdom, preprint, 12 authors.
This PaperVitamin DAll
Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised with COVID-19 are associated with greater disease severity: results of a local audit of practice
Grigorios Panagiotou, Su Ann Tee, Yasir Ihsan, Waseem Athar, Gabriella Marchitelli, Donna Kelly, Christopher S Boot, Nadia Stock, James Macfarlane, Adrian R Martineau, Graham Burns, Dr Richard Quinton
doi:10.1101/2020.06.21.20136903
Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised with COVID-19 are associated with greater disease severity: results of a local audit of practice.
manuscript. RQ is the guarantor of this work and attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted.
References
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Nonnecke, Mcgill, Ridpath, Acute phase response elicited by experimental bovine diarrhea virus (BVDV) infection is associated with decreased vitamin D and E status of vitamin-replete preruminant calves, Journal of dairy science, doi:10.3168/jds.2014-8293
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Romagnoli, Mascia, Cipriani, Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly, The Journal of clinical endocrinology and metabolism, doi:10.1210/jc.2008-0350
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