Vitamin D supplementation and COVID-19 risk: a population-based, cohort study

Vitamin D study #122 of 131 Meta Analysis

7/17 Pre-Exposure Prophylaxis study (treated before exposed to the virus)

Oristrell et al., Journal of Endocrinological Investigation, doi:10.1007/s40618-021-01639-9 (Peer Reviewed)
Vitamin D supplementation and COVID-19 risk: a population-based, cohort study

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Retrospective study of cholecalciferol and calcitriol supplementation in Catalonia showing a small but significant lower risk of cases with cholecalciferol, but no significant difference for mortality, or for calcitriol supplementation. Significant benefit was found for cases, severity, and mortality in patients achieving serum vitamin D levels ≥30ng/ml.

Oristrell et al., 7/17/2021, retrospective, Spain, Europe, peer-reviewed, 8 authors, dosage varies (calcifediol).

risk of death, 1.0% higher, RR 1.01, p = 0.91, calcifediol, univariate.

risk of death, 4.0% lower, RR 0.96, p = 0.37, cholecalciferol, univariate.

risk of COVID-19 case, 1.0% lower, RR 0.99, p = 0.65, calcifediol, univariate.

risk of COVID-19 case, 5.0% lower, RR 0.95, p = 0.004, cholecalciferol, multivariate.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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