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Vitamin D study #94 of 96
4/6 Pre-Exposure Prophylaxis study (treated before exposed to the virus)
Oristrell et al., Preprints, doi:10.20944/preprints202104.0173.v1 (Preprint)
Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-based Study
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Retrospective study of calcitriol supplementation with chronic kidney disease patients in Catalonia showing lower cases, severe cases, and mortality with supplementation.

Oristrell et al., 4/6/2021, retrospective, Spain, Europe, preprint, 10 authors, dosage calcifediol 0.3mg daily, mean daily dose.
risk of death, 43.0% lower, RR 0.57, p = 0.001, treatment 2296, control 3407, multivariate, patients with CKD stages 4-5.
risk of COVID-19 severe case, 43.0% lower, RR 0.57, p < 0.001, treatment 2296, control 3407, multivariate, patients with CKD stages 4-5.
risk of COVID-19 case, 22.0% lower, RR 0.78, p = 0.01, treatment 2296, control 3407, multivariate, patients with CKD stages 4-5.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
Details of all 96 studies
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