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0 0.5 1 1.5 2+ ICU admission 59% Improvement Relative Risk Mortality 24% Ventilation 9% c19vitamind.com Orchard et al. Vitamin D for COVID-19 Sufficiency Favors vitamin D Favors control
Orchard, 115 patient vitamin D sufficiency study: 59% lower ICU admission [p=0.001] and 9% lower ventilation [p=0.7] https://c19p.org/orchard
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Vitamin-D levels and intensive care unit outcomes of a cohort of critically ill COVID-19 patients
Orchard et al., Clin Chem Lab Med, doi:10.1515/cclm-2020-1567
19 Jan 2021    Source   PDF   Share   Tweet
Retrospective 165 hospitalized patients with known vitamin D levels, showing an associated between vitamin D deficiency and ICU admission. There was no statistically significant difference in clinical outcomes for ICU patients. It's unclear why authors do not provide clinical outcomes for all patients rather than ICU only.
risk of ICU admission, 58.8% lower, RR 0.41, p = 0.001, high D levels 9 of 40 (22.5%), low D levels 41 of 75 (54.7%), NNT 3.1, all hospitalized patients, >50 nmol/L.
risk of death, 24.1% lower, RR 0.76, p = 1.00, high D levels 1 of 9 (11.1%), low D levels 6 of 41 (14.6%), NNT 28, ICU patients only, >50 nmol/L.
risk of mechanical ventilation, 8.9% lower, RR 0.91, p = 0.70, high D levels 6 of 9 (66.7%), low D levels 30 of 41 (73.2%), NNT 15, ICU patients only, >50 nmol/L.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Orchard et al., 1/19/2021, retrospective, United Kingdom, Europe, peer-reviewed, 7 authors.
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