Factors Associated with Hospitalization and Disease Severity in a Racially and Ethnically Diverse Population of COVID-19 Patients

6/27 Analysis of outcomes based on serum levels

Mendy et al., medRxiv, doi:10.1101/2020.06.25.20137323 (Preprint)
Factors Associated with Hospitalization and Disease Severity in a Racially and Ethnically Diverse Population of COVID-19 Patients

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Retrospective 689 patients showing vitamin D deficiency associated with hospitalization and disease severity.

Mendy et al., 6/27/2020, retrospective, USA, North America, preprint, 4 authors.

risk of death, 7.0% lower, RR 0.93, p = 0.89, high D levels 21 of 600 (3.5%), low D levels 5 of 89 (5.6%), odds ratio converted to relative risk.

risk of combined death/ICU, 16.7% lower, RR 0.83, p < 0.001, high D levels 68 of 600 (11.3%), low D levels 23 of 89 (25.8%), odds ratio converted to relative risk.

risk of ICU admission, 55.3% lower, RR 0.45, p = 0.008, high D levels 47 of 600 (7.8%), low D levels 18 of 89 (20.2%), odds ratio converted to relative risk.

risk of hospitalization, 15.1% lower, RR 0.85, p < 0.001, high D levels 171 of 89 (192.1%), low D levels 45 of 89 (50.6%), odds ratio converted to relative risk.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 131 studies Meta Analysis

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