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Vitamin D study #9 of 109
6/27 Analysis of outcomes based on serum levels
Mendy et al., medRxiv, doi:10.1101/2020.06.25.20137323 (Preprint)
Factors Associated with Hospitalization and Disease Severity in a Racially and Ethnically Diverse Population of COVID-19 Patients
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Retrospective 689 patients showing vitamin D deficiency associated with hospitalization and disease severity.

Mendy et al., 6/27/2020, retrospective, USA, North America, preprint, 4 authors.
risk of death, 7.0% lower, RR 0.93, p = 0.89, high D levels 21 of 600 (3.5%), low D levels 5 of 89 (5.6%), odds ratio converted to relative risk.
risk of combined death/ICU, 16.7% lower, RR 0.83, p < 0.001, high D levels 68 of 600 (11.3%), low D levels 23 of 89 (25.8%), odds ratio converted to relative risk.
risk of ICU admission, 55.3% lower, RR 0.45, p = 0.008, high D levels 47 of 600 (7.8%), low D levels 18 of 89 (20.2%), odds ratio converted to relative risk.
risk of hospitalization, 15.1% lower, RR 0.85, p < 0.001, high D levels 171 of 89 (192.1%), low D levels 45 of 89 (50.6%), odds ratio converted to relative risk.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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