Mazziotti, 348 patient vitamin D late treatment study: 19% lower mortality [p=0.49], 67% higher ventilation [p=0.08], and 37% lower progression [p=0.006] https://c19p.org/mazziotti
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Vitamin D deficiency, secondary hyperparathyroidism and respiratory insufficiency in hospitalized patients with COVID-19
et al., J Endocrinol. Invest., doi:10.1007/s40618-021-01535-2
Retrospective 348 hospitalized patients in Italy showing vitamin D deficiency associated with acute hypoxemic respiratory failure. Vitamin D supplementation during hospitalization was not significantly associated with mortality or ventilation.
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risk of death, 19.0% lower, OR 0.81, p = 0.49, treatment 116, control 232, supplementation, RR approximated with OR.
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risk of mechanical ventilation, 67.0% higher, OR 1.67, p = 0.08, treatment 116, control 232, supplementation, RR approximated with OR.
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risk of death, 2.4% lower, RR 0.98, p = 0.91, high D levels 187, low D levels 161, odds ratio converted to relative risk, >12ng/mL, control prevalance approximated with overall prevalence, outcome based on serum levels.
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risk of acute hypoxemic respiratory failure, 37.0% lower, RR 0.63, p = 0.006, high D levels 72 of 187 (38.5%), low D levels 97 of 161 (60.2%), NNT 4.6, odds ratio converted to relative risk, >12ng/mL, outcome based on serum levels.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Mazziotti et al., 3/5/2021, retrospective, Italy, Europe, peer-reviewed, 11 authors, dosage varies.
Late treatment
is less effective
is less effective
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