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Vitamin D study #96 of 96
4/29 Early treatment study
Loucera et al., medRxiv, doi:10.1101/2021.04.27.21255937 (Preprint)
Real world evidence of calcifediol use and mortality rate of COVID-19 hospitalized in a large cohort of 16,401 Andalusian patients
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Retrospective 16,401 hospitalized patients in Spain showing a significant reduction in mortality associated with the prescription of vitamin D, especially calcifediol, within 15-30 days prior to hospitalization.

Loucera et al., 4/29/2021, retrospective, propensity score matching, Spain, Europe, preprint, 11 authors, dosage varies (calcifediol).
risk of death, 71.9% lower, RR 0.28, p < 0.001, treatment 193, control 193, calcifediol, <15 days before hospitalization, Cox model with inverse propensity weighting.
risk of death, 63.6% lower, RR 0.36, p < 0.001, treatment 210, control 210, calcifediol, <30 days before hospitalization, Cox model with inverse propensity weighting.
risk of death, 42.9% lower, RR 0.57, p < 0.001, treatment 358, control 358, cholecalciferol, <15 days before hospitalization, Cox model with inverse propensity weighting.
risk of death, 23.7% lower, RR 0.76, p < 0.03, treatment 416, control 416, cholecalciferol, <30 days before hospitalization, Cox model with inverse propensity weighting.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
Details of all 96 studies
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