Real world evidence of calcifediol use and mortality rate of COVID-19 hospitalized in a large cohort of 16,401 Andalusian patients

Vitamin D study #101 of 126 Meta Analysis

Loucera et al., medRxiv, doi:10.1101/2021.04.27.21255937 (Preprint)
Real world evidence of calcifediol use and mortality rate of COVID-19 hospitalized in a large cohort of 16,401 Andalusian patients

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Retrospective 16,401 hospitalized patients in Spain showing a significant reduction in mortality associated with the prescription of vitamin D, especially calcifediol, within 15-30 days prior to hospitalization.

Loucera et al., 4/29/2021, retrospective, propensity score matching, Spain, Europe, preprint, 11 authors, dosage varies (calcifediol).

risk of death, 71.9% lower, RR 0.28, p < 0.001, treatment 193, control 193, calcifediol, <15 days before hospitalization, Cox model with inverse propensity weighting.

risk of death, 63.6% lower, RR 0.36, p < 0.001, treatment 210, control 210, calcifediol, <30 days before hospitalization, Cox model with inverse propensity weighting.

risk of death, 42.9% lower, RR 0.57, p < 0.001, treatment 358, control 358, cholecalciferol, <15 days before hospitalization, Cox model with inverse propensity weighting.

risk of death, 23.7% lower, RR 0.76, p < 0.03, treatment 416, control 416, cholecalciferol, <30 days before hospitalization, Cox model with inverse propensity weighting.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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