Li, 18,148 patient vitamin D sufficiency study: 9% fewer cases [p=0.24] https://c19p.org/li6
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Assessment of the Association of Vitamin D Level With SARS-CoV-2 Seropositivity Among Working-Age Adults
et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2021.11634
Cohort study of 18,148 patients in the USA showing low vitamin D associated with COVID-19 PCR+ status before adjustments but not after.Authors state that "low vitamin D levels were not independently associated with the
risk of seropositivity", however there is significant correlation between some adjustment variables and vitamin D levels in the logistic regression that prevent drawing this conclusion [statisticsbyjim.com]. Details of the logistic regression in the matched sample set are not provided.Authors analyze only 20ng/mL and 30ng/mL cutoff points, other studies use 10ng/mL (or 12), where more significant differences are typically seen.
risk of seropositivity", however there is significant correlation between some adjustment variables and vitamin D levels in the logistic regression that prevent drawing this conclusion [statisticsbyjim.com]. Details of the logistic regression in the matched sample set are not provided.Authors analyze only 20ng/mL and 30ng/mL cutoff points, other studies use 10ng/mL (or 12), where more significant differences are typically seen.
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risk of case, 8.6% lower, RR 0.91, p = 0.24, high D levels 610 of 13,650 (4.5%), low D levels 290 of 4,498 (6.4%), adjusted per study, odds ratio converted to relative risk, >20ng/mL, Figure 2.
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risk of case, 12.4% lower, RR 0.88, p = 0.07, high D levels 289 of 7,272 (4.0%), low D levels 611 of 10,876 (5.6%), adjusted per study, odds ratio converted to relative risk, >30ng/mL, Figure 2.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Li et al., 5/19/2021, retrospective, USA, North America, peer-reviewed, 4 authors.
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