1/11 Analysis of outcomes based on serum levels
et al., Aging and Disease, doi:10.14336/AD.2020.1108 (Peer Reviewed)
Metabolic Healthy Obesity, Vitamin D Status, and Risk of COVID-19
Metabolic Healthy Obesity, Vitamin D Status, and Risk of COVID-19
UK Biobank retrospective 353,299 patients showing that vitamin D insufficiency and deficiency are associated with increased COVID-19 risk. This study also analyzes metabolic/obesity phenotypes and the combination with vitamin D status.
Li et al., 1/11/2021, retrospective, population-based cohort, United Kingdom, Europe, peer-reviewed, 6 authors.
risk of COVID-19 severe case, 36.2% lower, RR 0.64, p < 0.001, odds ratio converted to relative risk, >25nmol/L.
risk of hospitalization, 28.8% lower, RR 0.71, p < 0.001, odds ratio converted to relative risk, >25nmol/L.
risk of COVID-19 case, 29.5% lower, RR 0.71, p < 0.001, odds ratio converted to relative risk, >25nmol/L.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.
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