4/28 Analysis of outcomes based on serum levels
et al., medRxiv, doi:10.1101/2020.04.24.20075838 (Preprint)
Vitamin D Insufficiency is Prevalent in Severe COVID-19
Vitamin D Insufficiency is Prevalent in Severe COVID-19
Analysis of 20 hospitalized COVID-19 patients, 13 requiring ICU admission. 84.6% of the ICU patients had low vitamin D levels versus 57.1% of the non-ICU patients.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
Lau et al., 4/28/2020, retrospective, USA, North America, preprint, 7 authors.
risk of ICU admission, 45.0% lower, RR 0.55, p = 0.29, high D levels 2 of 5 (40.0%), low D levels 11 of 15 (73.3%), >30ng/mL.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
