2/23 Late treatment study
et al., Research Square, doi:10.21203/rs.3.rs-152494/v1 (Preprint)
Impact of Pulse D Therapy on The Inflammatory Markers in Patients With COVID-19
Impact of Pulse D Therapy on The Inflammatory Markers in Patients With COVID-19
RCT 44 treatment and 43 control patients with vitamin D levels <30ng/ml, showing significant reduction in inflammatory markers with treatment of 60,000IU vitamin D per day for 8 days (10 days for BMI >25). Death and ICU admission was lower in the treatment group but not statistically significant.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
Lakkireddy et al., 2/23/2021, Randomized Controlled Trial, India, South Asia, preprint, mean age 45.5, 9 authors, dosage 60,000IU days 1-8.
risk of death, 60.9% lower, RR 0.39, p = 0.27, treatment 2 of 44 (4.5%), control 5 of 43 (11.6%).
risk of ICU admission, 21.8% lower, RR 0.78, p = 0.74, treatment 4 of 44 (9.1%), control 5 of 43 (11.6%).
hospitalization time, 1.2% lower, relative time 0.99, p = 0.88, treatment 44, control 43.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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