Lakkireddy, 87 patient vitamin D late treatment RCT: 61% lower mortality [p=0.27], 22% lower ICU admission [p=0.74], and 7% shorter hospitalization [p=0.9] https://c19p.org/lakkireddy
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Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease
et al., Scientific Reports, doi:10.1038/s41598-021-90189-4 (preprint 2/23/21)
RCT 44 treatment and 43 control patients with vitamin D levels <30ng/ml, showing significant reduction in inflammatory markers with treatment of 60,000IU vitamin D per day for 8 days (10 days for BMI >25). Death and ICU admission was lower in the treatment group but not statistically significant.This study was retracted due to incorrect claims from an anti-treatment researcher. For discussion see [vdmeta.com].
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risk of death, 60.9% lower, RR 0.39, p = 0.27, treatment 2 of 44 (4.5%), control 5 of 43 (11.6%), NNT 14.
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risk of ICU admission, 21.8% lower, RR 0.78, p = 0.74, treatment 4 of 44 (9.1%), control 5 of 43 (11.6%), NNT 39.
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hospitalization time, 7.1% lower, relative time 0.93, p = 0.90, treatment 44, control 43.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Lakkireddy et al., 2/23/2021, Randomized Controlled Trial, India, South Asia, peer-reviewed, mean age 45.5, 9 authors, dosage 60,000IU days 1-8, 8 or 10 days depending on BMI.
Late treatment
is less effective
is less effective
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