Khan: Oral Co-Supplementation of Curcumin, Quercetin, and Vitamin D3 as an Adjuvant Therapy for Mild to Moderate Symptoms of COVID-19—Results From a Pilot Open-Label, Randomized Controlled Trial

Khan, 50 patient vitamin D early treatment RCT: 33% improved recovery [p=0.15] and 50% improved viral clearance [p=0.009] https://c19p.org/khan4

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Oral Co-Supplementation of Curcumin, Quercetin, and Vitamin D3 as an Adjuvant Therapy for Mild to Moderate Symptoms of COVID-19—Results From a Pilot Open-Label, Randomized Controlled Trial

Khan et al., Frontiers in Pharmacology, doi:10.3389/fphar.2022.898062, NCT05130671 (history)

1 May 2022 Source PDF Share Tweet

RCT 50 COVID+ outpatients in Pakistan, 25 treated with curcumin, quercetin, and vitamin D, showing significantly faster viral clearance, significantly improved CRP, and faster resolution of acute symptoms (p=0.154). 168mg curcumin, 260mg quercetin and 360IU cholecalciferol.

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risk of no recovery, 33.3% lower, RR 0.67, p = 0.15, treatment 10 of 25 (40.0%), control 15 of 25 (60.0%), NNT 5.0.

relative CRP reduction, 39.1% better, RR 0.61, p = 0.006, treatment 25, control 25.

risk of no viral clearance, 50.0% lower, RR 0.50, p = 0.009, treatment 10 of 25 (40.0%), control 20 of 25 (80.0%), NNT 2.5.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Khan et al., 1 May 2022, Randomized Controlled Trial, Pakistan, peer-reviewed, 7 authors, study period 2 September, 2021 - 28 November, 2021, dosage 360IU days 1-14, this trial uses multiple treatments in the treatment arm (combined with curcumin and quercetin) - results of individual treatments may vary, trial NCT05130671 (history).

Contact: amjadkhan@lumhs.edu.pk.

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