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Vitamin D study #30 of 167   Meta Analysis
9/17 Analysis of outcomes based on serum levels
Kaufman et al., PLOS One, doi:10.1371/journal.pone.0239252 (Peer Reviewed)
SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels
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Analysis of 191,779 patients in the US finding COVID-19 positivity strongly and inversely associated with circulating 25(OH)D levels. The relationship persists across latitudes, races/ethnicities, gender, and age ranges.
COVID-19 adjusted odds ratio OR 0.984 per ng/mL increment, p<0.001). The decrease in positivity rate appeared to plateau as values approached 55 ng/mL.
Patients with high D levels (>55 ng/mL) compared to patients with very low D levels (<20 ng/mL) have a much lower risk of COVID-19 cases, with unadjusted RR 0.47, p<0.001.
Kaufman et al., 9/17/2020, retrospective, population-based cohort, USA, North America, peer-reviewed, median age 54.0, 5 authors.
risk of COVID-19 case, 53.0% lower, RR 0.47, p < 0.001, high D levels 12321, low D levels 39190, >55 ng/mL vs. <20 ng/mL.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 167 studies   Meta Analysis
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