Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All vitamin D studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 79% Improvement Relative Risk Severe case 71% Vitamin D for COVID-19  Karonova et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 80 patients in Russia Lower severe cases with higher vitamin D levels (p=0.05) c19early.org Karonova et al., Infectology, December 2020 Favors vitamin D Favors control

Serum 25(oH)D level in patients with CoVID-19

Karonova et al., Infectology, doi:10.22625/2072-6732-2020-12-3-21-27
Dec 2020  
  Post
  Facebook
Share
  Source   PDF   All   Meta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 7 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
Retrospective 80 COVID-19 patients showing low vitamin D levels associated with severity and mortality.
This is the 35th of 195 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 5061 vigintillion).
risk of death, 79.4% lower, RR 0.21, p = 0.11, high D levels 1 of 23 (4.3%), low D levels 12 of 57 (21.1%), NNT 6.0, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk, >20ng/ml.
risk of severe case, 71.1% lower, RR 0.29, p = 0.05, high D levels 3 of 23 (13.0%), low D levels 22 of 57 (38.6%), NNT 3.9, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk, >20ng/ml.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Karonova et al., 31 Dec 2020, retrospective, Russia, peer-reviewed, 3 authors.
This PaperVitamin DAll
serum 25(oH)D level in patients with CoVID-19
T L Karonova, А Т Andreeva, М А Vashukova
Journal Infectology, doi:10.22625/2072-6732-2020-12-3-21-27
Введение Единичные исследования, проведенные с момента начала пандемии COVID-19, продемонстрировали, что дефицит витамина D может быть одним из факторов, повышающих заболеваемость и ухудшающих течение респираторной вирусной инфекции (ОРВИ), вызванной SARS-CoV-2 [1]. Иммуномодулирующие эффекты витамина D хорошо изучены и связаны во многом с экспрессией фермента CYP27B1 в клетках иммунной систе-
References
Adams, Adams, Ren, Vitamin d-directed rheostatic regulation of monocyte antibacterial responses, J. Immunol, doi:10.4049/jimmunol.0803736
Adams, Adams, Ren, Vitamin d-directed rheostatic regulation of monocyte antibacterial responses, J. Immunol, doi:10.4049/jimmunol.0803736
Alipio, Vitamin D Supplementation Could Possibly Improve Clinical Outcomes of Patients Infected with Coronavirus, doi:10.2139/ssrn.357148426
Alipio, Vitamin D Supplementation Could Possibly Improve Clinical Outcomes of Patients Infected with Coronavirus, doi:10.2139/ssrn.357148426
Baeke, Baeke, Korf, Overbergh, Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system, J Steroid Biochem Mol Biol, doi:10.1016/j.js-bmb.2010.03.037
Baeke, Baeke, Korf, Overbergh, Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system, J Steroid Biochem Mol Biol, doi:10.1016/j.js-bmb.2010.03.037
Beard, Bearden, Striker, None, J. Clin. Virol
Beard, Vitamin, Beard, Bearden, Striker, the anti-viral state, J. Clin. Virol, doi:10.1016/j.jcv.2010.12.006
Beard, Vitamin, the anti-viral state, J.A
Campbell, Campbell, Wu, Rapid response to Elisabeth Mahase E: Covid-19: what treatments are being investigated, doi:10.1136/bmj.m1252
Campbell, Campbell, Wu, Rapid response to Elisabeth Mahase E: Covid-19: what treatments are being investigated, doi:10.1136/bmj.m1252
Cannell, Cannell, Vieth, Umhau, Epidemic influenza and vitamin, // Epidemiol. Infect, doi:10.1017/S0950268806007175
Cannell, Epidemic influenza and vitamin D
Cannell, Vieth, Umhau, None, Epidemiol. Infect, doi:10.1017/S0950268806007175
Cantorna, Snyder, Lin, Vitamin D and 1,25(OH)2D regulation of T cells, Nutrients, doi:10.3390/nu7043011
Cantorna, Snyder, Lin, Vitamin D and 1,25(OH)2D regulation of T cells, Nutrients, doi:10.3390/nu7043011
Cohen-Lahav, Vitamin D decreases NFκB activity by increasing IκBα levels
Cohen-Lahav, Vitamin D decreases NFκB activity by increasing IκBα levels
Dediego, Nieto-Torres, Nava, Inhibition of NF-αB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival, J Virol, doi:10.1128/JVI.02576-13
Dediego, Nieto-Torres, Nava, Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival, doi:10.1128/JVI.02576-13
Ginde, Ginde, Mansbach, Camargo, Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey, Arch. Intern. Med
Ginde, Ginde, Mansbach, Camargo, Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey, Arch. Intern. Med
Han, Han, Jones, High dose vitamin D administration in ventilated intensive care unit patients: A Pilot Double Blind Randomized Controlled Trial, J. Clin. Trans. Endocrinol, doi:10.1016/j.jcte.2016.04.004
Han, Han, Jones, High dose vitamin D administration in ventilated intensive care unit patients: A Pilot Double Blind Randomized Controlled Trial, J. Clin. Trans. Endocrinol, doi:10.1016/j.jcte.2016.04.004
Hewison, Hewison, Freeman, Hughes, Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells, J. Immunol
Hewison, Hewison, Freeman, Hughes, Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells, J. Immunol, doi:10.4049/jimmu-nol.170.11.5382
Holick, Holick, Binkley, Bischoff-Ferrari, Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline, J Clin Endocrinol Metab, doi:10.1210/jc.2011-0385
Huang, Wang, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, doi:10.1016/S0140-6736(20)30183-5
Huang, Wang, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, doi:10.1016/S0140-6736(20)30183-5
Hussain, Hussain, Bhowmik, Do, Moreira, COVID-19 and diabetes: Knowledge in progress, doi:10.1016/j.diabres.2020.10814224
Hussain, Hussain, Bhowmik, Do, Moreira, COVID-19 and diabetes: Knowledge in progress, doi:10.1016/j.diabres.2020.10814224
Jeffery, Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3, J. Immu, doi:10.4049/jimmunol.0803217
Jeffery, Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3, J. Immu, doi:10.4049/jimmunol.0803217
Karonova, Andreeva, Nikitina, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline, doi:10.1016/j.js-bmb.2016.03.026
Karonova, Karonova, Andreeva, Nikitina, Prevalence of Vitamin D deficiency in the North-West region of Russia: A cross-sectional study / T, J Steroid Biochem Mol Biol, doi:10.1016/j.js-bmb.2016.03.026
Karonova, study / T
Karonova, Авторский коллектив: Каронова Татьяна Леонидовна -главный научный сотрудник, руководитель НИЛ клинической эндокринологии, профессор кафедры внутренних болезней Национального медицинского исследовательского центра им, А. Алмазова, д.м
Laaksi, Vitamin D and respiratory infection in adults / I, Laaksi. // Proc. Nutr. Soc, doi:10.1017/S0029665111003351
Laaksi, Vitamin D and respiratory infection in adults / I, Laaksi. // Proc. Nutr. Soc, doi:10.1017/S0029665111003351
Lavie, COVID-19 and obesity: links and risks / C
Lavie, COVID-19 and obesity: links and risks / C
Lavie, Sanchis-Gomar, Henry, // Expert, Rev Endocrinol Metab, doi:10.1080/17446651.2020.1767589
Lavie, Sanchis-Gomar, Henry, // Expert, Rev Endocrinol Metab, doi:10.1080/17446651.2020.1767589
Lemire, Adams, Kermani-Arab, 1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitro, J. Immunol
Lemire, Adams, Kermani-Arab, 1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitro, J. Immunol
Liu, Liu, Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response, doi:10.1126/science.1123933
Liu, Liu, Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response, doi:10.1126/science.1123933
Martineau, Martineau, Jolliffe, Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and metaanalysis of individual participant data, doi:10.1136/bmj.i6583
Martineau, Martineau, Jolliffe, Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and metaanalysis of individual participant data, doi:10.1136/bmj.i6583
Pham, Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis, doi:10.3390/ijerph16173020
Pham, Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis, doi:10.3390/ijerph16173020
Pigarova, Russian Association of endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults, // Problems of endocrinology
Rondanelli, Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds/ M, Evid. Based Complement. Alternat. Med, doi:10.1155/2018/5813095
Rondanelli, Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds/ M, Evid. Based Complement. Alternat. Med, doi:10.1155/2018/5813095
Wang, Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, doi:10.1001/jama.2020.1585.1
Wang, Zhou, Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, doi:10.1001/jama.2020.1585.133
White, Coronavirus (COVID-19) related deaths by ethnic group, J. Hyg
White, Coronavirus (COVID-19) related deaths by ethnic group, J. Hyg
White, Regulation of intracrine production of 1,25-dihydroxyvitamin D and its role in innate immune defense against infection / J. White, Arch. Biochem. Biophys
White, Regulation of intracrine production of 1,25-dihydroxyvitamin D and its role in innate immune defense against infection / J. White, Arch. Biochem. Biophys
Yang, Yang, Zhang, Xu, Vankadari et al., Effect of Vitamin D on ACE2 and Vitamin D receptor expression in rats with LPS-induced acute lung injury, doi:10.3760/cma.j.issn.1671-0282.2016.12.01615
Yang, Yang, Zhang, Xu, Vankadari et al., Effect of Vitamin D on ACE2 and Vitamin D receptor expression in rats with LPS-induced acute lung injury, doi:10.3760/cma.j.issn.1671-0282.2016.12.01615
Zhonghua, The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases
Zhonghua, The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases
Zhou, Zhou, Yu, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study, doi:10.1016/S0140-6736(20)30566-3
Каронова, Витамин D как фактор повышения иммунитета и снижения риска развития острых респираторных вирусных инфекций и COVID-19
Пигарова, Клинические рекомендации российской ассоциации эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых / Е
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit