Junior: Chronic diseases, chest computed tomography, and laboratory tests as predictors of severe respiratory failure and death in elderly Brazilian patients hospitalized with COVID-19: a prospective cohort study

Junior, 201 patient vitamin D prophylaxis study: 22% lower mortality [p=0.61] and 31% lower progression [p=0.26] https://c19p.org/junior

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Chronic diseases, chest computed tomography, and laboratory tests as predictors of severe respiratory failure and death in elderly Brazilian patients hospitalized with COVID-19: a prospective cohort study

Junior et al., BMC Geriatrics, doi:10.1186/s12877-022-02776-3

17 Feb 2022 Source PDF Share Tweet

Prospective study of 201 COVID+ hospitalized adults in Brazil, mean age 73, showing a lower risk of mortality and respiratory failure with vitamin D supplementation in unadjusted results, without statistical significance, and a higher risk of progression to mechanical ventilation with vitamin D levels <40ng/dl.

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risk of death, 22.1% lower, RR 0.78, p = 0.61, treatment 8 of 113 (7.1%), control 8 of 88 (9.1%), NNT 50, excluded in exclusion analyses: unadjusted results with no group details.

risk of progression, 30.8% lower, RR 0.69, p = 0.26, treatment 16 of 113 (14.2%), control 18 of 88 (20.5%), NNT 16, respiratory failure, excluded in exclusion analyses: unadjusted results with no group details.

risk of mechanical ventilation, 84.4% lower, OR 0.16, p = 0.03, cutoff 40ng/dl, inverted to make OR<1 favor high D levels (≥40ng/dl), cutoff ≥40ng/dl, risk of mechanical ventilation for vitamin D levels >40ng/ml, RR approximated with OR, outcome based on serum levels.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Junior et al., 17 Feb 2022, prospective, Brazil, peer-reviewed, 6 authors, dosage not specified.

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