Vitamin D deficiency is associated with higher hospitalisation risk from COVID-19: a retrospective case-control study

Vitamin D study #118 of 131 Meta Analysis

6/17 Analysis of outcomes based on serum levels

Jude et al., Journal of Clinical Endocrinology & Metabolism, doi:10.1210/clinem/dgab439 (Peer Reviewed)
Vitamin D deficiency is associated with higher hospitalisation risk from COVID-19: a retrospective case-control study

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Retrospective 80,670 people in the UK with vitamin D levels measured within the last 12 months, showing higher risk of hospitalization with low vitamin D levels.

Jude et al., 6/17/2021, retrospective, United Kingdom, Europe, peer-reviewed, 5 authors.

risk of hospitalization, 71.6% lower, RR 0.28, p < 0.001, adjusted per study, odds ratio converted to relative risk, >25 nmol/L, control prevalence approximated with overall prevalence.

risk of hospitalization, 57.9% lower, RR 0.42, p < 0.001, adjusted per study, odds ratio converted to relative risk, >50 nmol/L, control prevalence approximated with overall prevalence.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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