Jevalikar, 197 patient vitamin D late treatment study: 82% lower mortality [p=0.12], 34% lower ICU admission [p=0.29], and 32% lower need for oxygen therapy [p=0.06] https://c19p.org/jevalikar
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Lack of association of baseline 25-hydroxyvitamin D levels with disease severity and mortality in Indian patients hospitalized for COVID-19
et al., Scientific Reports, doi:10.1038/s41598-021-85809-y (preprint 12/28)
Prospective study of 410 hospitalized patients in India showing lower mortality and ICU admission with cholecalciferol treatment, although not statistically significant with the small number of cases. The median total dose was 60000IU.No significant difference was found for outcomes based on baseline vitamin D deficiency, however this analysis does not appear to account for the deficient patients that were treated with vitamin D.
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risk of death, 82.0% lower, RR 0.18, p = 0.12, treatment 1 of 128 (0.8%), control 3 of 69 (4.3%), NNT 28.
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risk of ICU admission, 33.7% lower, RR 0.66, p = 0.29, treatment 16 of 128 (12.5%), control 13 of 69 (18.8%), NNT 16.
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risk of oxygen therapy, 31.7% lower, RR 0.68, p = 0.06, treatment 38 of 128 (29.7%), control 30 of 69 (43.5%), NNT 7.3.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Jevalikar et al., 12/28/2020, prospective, India, South Asia, peer-reviewed, 8 authors, dosage 60,000IU single dose, median total dose.
Late treatment
is less effective
is less effective
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