Identification of drugs associated with reduced severity of COVID-19: A case-control study in a large population

Vitamin D study #124 of 131 Meta Analysis

7/27 Pre-Exposure Prophylaxis study (treated before exposed to the virus)

Israel et al., Epidemiology and Global Health Microbiology and Infectious Disease, doi:10.7554/eLife.68165 (Peer Reviewed)
Identification of drugs associated with reduced severity of COVID-19: A case-control study in a large population

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Case control study examining medication usage with a healthcare database in Israel, showing lower risk of hospitalization with vitamin D (defined as being picked up within 35 days prior to PCR+). Other patients may have acquired vitamin D supplements outside of the healthcare system.

Israel et al., 7/27/2021, retrospective, Israel, Middle East, peer-reviewed, 10 authors.

risk of hospitalization, 9.1% lower, RR 0.91, p = 0.003, treatment 737 of 2406 (30.6%), control 6216 of 18453 (33.7%), odds ratio converted to relative risk, PCR+, cohort 2.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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