The link between vitamin D deficiency and Covid-19 in a large population

Vitamin D study #24 of 131 Meta Analysis

9/10 Analysis of outcomes based on serum levels

Israel et al., medRxiv, doi:https://www.medrxiv.org/content/10.1101/2020.09.04.20188268v1 (Preprint)
The link between vitamin D deficiency and Covid-19 in a large population

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Large observational population study showing a strong association between vitamin D deficiency and COVID-19.

Israel et al., 9/10/2020, retrospective, Israel, Middle East, preprint, 8 authors.

risk of COVID-19 case, 21.3% lower, RR 0.79, p < 0.001, high D levels 2601 of 32712 (8.0%), low D levels 5011 of 39485 (12.7%), adjusted per study, odds ratio converted to relative risk, multivariable >75 nmol/L vs. <30 nmol/L.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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