Gönen: Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1

Gönen, 162 patient vitamin D sufficiency study: 21% lower hospitalization [p=0.11] https://c19p.org/gonen

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Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1

Gönen et al., Nutrients, doi:10.3390/nu13114047

12 Nov 2021 Source PDF Share Tweet

Retrospective 867 hospitalized COVID-19 patients in Turkey, showing worse outcomes with vitamin D deficiency (without statistical significance); followed by a prospective study of 210 patients with vitamin D supplementation for those that were deficient, showing significantly lower mortality compared to the retrospective study without treatment.

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risk of death, 65.8% lower, RR 0.34, p = 0.62, high D levels (≥12ng/mL) 1 of 80 (1.2%), low D levels (<12ng/mL) 3 of 82 (3.7%), NNT 42, retrospective study.

risk of ICU admission, 16.9% lower, RR 0.83, p = 1.00, high D levels (≥12ng/mL) 4 of 77 (5.2%), low D levels (<12ng/mL) 5 of 80 (6.2%), NNT 95, retrospective study.

hospital stay >8 days, 21.1% lower, RR 0.79, p = 0.11, high D levels (≥12ng/mL) 40 of 78 (51.3%), low D levels (<12ng/mL) 52 of 80 (65.0%), NNT 7.3, retrospective study.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Gönen et al., 12 Nov 2021, retrospective, Turkey, peer-reviewed, 20 authors, dosage varies.

Contact: karraspiros@yahoo.gr, duygugezenak@iuc.edu.tr, duygugezenak@gmail.com, erdinc.dursun@iuc.edu.tr, erdincdu@gmail.com.

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