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0 0.5 1 1.5 2+ Mortality -5% Improvement Relative Risk Mortality (b) 45% Oxygen therapy 55% Hospitalization 4% c19vitamind.com Gavioli et al. Vitamin D for COVID-19 Sufficiency Favors vitamin D Favors control
Gavioli, 437 patient vitamin D sufficiency study: 5% higher mortality [p=0.83], 55% lower need for oxygen therapy [p=0.0002], and 4% lower hospitalization [p=0.41] https://c19p.org/gavioli
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An Evaluation of Serum 25-Hydroxy Vitamin D Levels in Patients with COVID-19 in New York City
Gavioli et al., Journal of the American College of Nutrition, doi:10.1080/07315724.2020.1869626
19 Feb 2021    Source   PDF   Share   Tweet
Retrospective 437 mostly serious condition (85% hospitalized) patients in New York, showing vitamin D deficiency associated with increased likelihood of oxygen support, but no association with mortality and hospitalization. Multivariate analysis excluded variables with p > 0.2 in univariate analysis. Adjustment for factors correlated with vitamin D may obscure the effect of vitamin D levels.
risk of death, 4.7% higher, RR 1.05, p = 0.83, high D levels 80 of 260 (30.8%), low D levels 52 of 177 (29.4%), >20ng/ml.
risk of death, 44.8% lower, RR 0.55, p < 0.001, high D levels 102 of 376 (27.1%), low D levels 30 of 61 (49.2%), NNT 4.5, >10ng/ml.
risk of oxygen therapy, 55.2% lower, RR 0.45, p < 0.001, high D levels 127 of 260 (48.8%), low D levels 116 of 177 (65.5%), NNT 6.0, adjusted per study, >20ng/ml, multivariate.
risk of hospitalization, 3.6% lower, RR 0.96, p = 0.41, high D levels 218 of 260 (83.8%), low D levels 154 of 177 (87.0%), NNT 32, >20ng/ml.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Gavioli et al., 2/19/2021, retrospective, USA, North America, peer-reviewed, 4 authors.
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