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Vitamin D study #108   Meta Analysis
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Case 79% Imp. Relative Risk, 95% CI Gaudio: Vitamin D Levels Are Reduced at the Time of Hospital Adm.. c19vitamind.com/gaudio.html Favors vitamin D Favors control
3/27 Analysis of outcomes based on serum levels
Gaudio et al., International Journal of Environmental Research and Public Health, doi:10.3390/ijerph18073491 (Peer Reviewed)
Vitamin D Levels Are Reduced at the Time of Hospital Admission in Sicilian SARS-CoV-2-Positive Patients
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Retrospective 50 COVID-19 hospitalized patients in Italy with vitamin D levels measured on admission, and 100 matched control patients, showing significantly lower vitamin D levels in COVID-19 patients. Vitamin D levels were also lower in COVID-19 patients with severe cases, without reaching statistical significance (p = 0.08, details not provided).
risk of case, 79.3% lower, RR 0.21, p < 0.001, high D levels 27 of 50 (54.0%) cases, 85 of 100 (85.0%) controls, case control OR.
Gaudio et al., 3/27/2021, retrospective, Italy, Europe, peer-reviewed, 6 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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