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0 0.5 1 1.5 2+ Mortality 93% Improvement Relative Risk Ventilation 50% ICU admission 50% NIV 48% c19vitamind.com Fiore et al. Vitamin D for COVID-19 LATE TREATMENT Favors vitamin D Favors control
Fiore, 116 patient vitamin D late treatment study: 93% lower mortality [p=0.02], 50% lower ventilation [p=0.36], 50% lower ICU admission [p=0.36], and 48% lower progression [p=0.04] https://c19p.org/fiore2
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Effectiveness of Vitamin D Supplements among Patients Hospitalized for COVID-19: Results from a Monocentric Matched-Cohort Study
Fiore et al., Healthcare, doi:10.3390/healthcare10050956
22 May 2022    Source   PDF   Share   Tweet
Retrospective 116 patients with D levels < 30ng/mL, 58 treated with vitamin D 100,000IU daily for two days, and 58 matched controls, showing significantly lower mortality with treatment.
risk of death, 92.7% lower, RR 0.07, p = 0.01, treatment 3 of 58 (5.2%), control 11 of 58 (19.0%), NNT 7.2, adjusted per study, odds ratio converted to relative risk, multivariable.
risk of mechanical ventilation, 50.0% lower, RR 0.50, p = 0.36, treatment 4 of 58 (6.9%), control 8 of 58 (13.8%), NNT 14.
risk of ICU admission, 50.0% lower, RR 0.50, p = 0.36, treatment 4 of 58 (6.9%), control 8 of 58 (13.8%), NNT 14.
NIV, 47.8% lower, RR 0.52, p = 0.04, treatment 12 of 58 (20.7%), control 23 of 58 (39.7%), NNT 5.3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Fiore et al., 5/22/2022, retrospective, matched cohort, Italy, Europe, peer-reviewed, mean age 62.5, 10 authors, dosage 100,000IU days 1-2.
Contact: vitofiore30010516@gmail.com (corresponding author), andreadevitoaho@gmail.com, paola.bagella@tiscali.it, princic_e@hotmail.com, annaanto82@gmail.com, dentilucia@outlook.it, giordano@uniss.it, babuder@uniss.it, imaida@uniss.it, agfois@uniss.it.
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This PaperVitamin DAll
Late treatment
is less effective
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