Ferrer-Sánchez: Serum 25(OH) Vitamin D Levels in Pregnant Women with Coronavirus Disease 2019 (COVID-19): A Case-Control Study

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Ferrer-Sánchez, 82 patient vitamin D sufficiency study: 63% fewer cases [p=0.01] https://c19p.org/ferrersanchez

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Serum 25(OH) Vitamin D Levels in Pregnant Women with Coronavirus Disease 2019 (COVID-19): A Case-Control Study

Ferrer-Sánchez et al., International Journal of Environmental Research and Public Health, doi:10.3390/ijerph19073965

26 Mar 2022 Source PDF Share Tweet

Retrospective 256 pregnant women, 82 with COVID-19 and 174 controls, showing significantly lower vitamin D levels for COVID-19 patients.

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risk of ICU admission, 81.8% lower, RR 0.18, p = 1.00, high D levels (≥20ng/mL) 0 of 9 (0.0%), low D levels (<20ng/mL) 4 of 73 (5.5%), NNT 18, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), excluded in exclusion analyses: unadjusted results with no group details.

risk of moderate/severe case, 88.7% lower, RR 0.11, p = 1.00, high D levels (≥20ng/mL) 0 of 9 (0.0%), low D levels (<20ng/mL) 7 of 73 (9.6%), NNT 10, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), excluded in exclusion analyses: unadjusted results with no group details.

risk of case, 62.7% lower, OR 0.37, p = 0.01, cutoff 20ng/mL, adjusted per study, inverted to make OR<1 favor high D levels (≥20ng/mL), multivariable, RR approximated with OR.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Ferrer-Sánchez et al., 26 Mar 2022, retrospective, Spain, peer-reviewed, 7 authors.

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