Analysis of 33 hospitalized COVID-19 patients with respiratory failure requiring FiO2 greater than 0.4.
Intubation hazard ratio for vitamin D sufficiency HR 0.31, p
Faul et al., 6/30/2020, retrospective, Ireland, Europe, peer-reviewed, 9 authors.
risk of mechanical ventilation, 69.0% lower, RR 0.31, p = 0.03, high D levels 4 of 21 (19.0%), low D levels 8 of 12 (66.7%), adjusted per study, >30nmol/L.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.