Vitamin D Deficiency and ARDS after SARS-CoV-2 Infection

Vitamin D study #11 of 131 Meta Analysis

6/30 Analysis of outcomes based on serum levels

Faul et al., Irish Medical Journal, 113:5, 84 (Peer Reviewed)
Vitamin D Deficiency and ARDS after SARS-CoV-2 Infection

Analysis of 33 hospitalized COVID-19 patients with respiratory failure requiring FiO2 greater than 0.4.

Intubation hazard ratio for vitamin D sufficiency HR 0.31, p = 0.03.

Faul et al., 6/30/2020, retrospective, Ireland, Europe, peer-reviewed, 9 authors.

risk of mechanical ventilation, 69.0% lower, RR 0.31, p = 0.03, high D levels 4 of 21 (19.0%), low D levels 8 of 12 (66.7%), adjusted per study, >30nmol/L.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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