Effects of Ivermectin-azithromycin-cholecalciferol combined therapy on COVID-19 infected patients: A proof of concept study

Vitamin D study #18 of 131 Meta Analysis

8/15 Early treatment study

Espitia-Hernandez et al., Biomedical Research, 31:5 (Peer Reviewed)
Effects of Ivermectin-azithromycin-cholecalciferol combined therapy on COVID-19 infected patients: A proof of concept study

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Small study with 28 patients treated with ivermectin + AZ + cholecalciferol and 7 control patients.

All treated patients were PCR- at day 10 while all control patients remained PCR+. The mean duration of symptoms was 3 days in the treatment group and 10 days in the control group.

Espitia-Hernandez et al., 8/15/2020, retrospective, Mexico, North America, peer-reviewed, 5 authors, dosage 8,000IU daily, 4000IU twice daily for 30 days, this trial uses multiple treatments in the treatment arm (combined with ivermectin and azithromycin) - results of individual treatments may vary.

risk of viral+ at day 10, 97.2% lower, RR 0.03, p < 0.001, treatment 0 of 28 (0.0%), control 7 of 7 (100.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), treatment also with IVM and AZ.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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